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. 1991 Jul 1;88(13):5754–5758. doi: 10.1073/pnas.88.13.5754

Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

P Horal 1, W W Hall 1, B Svennerholm 1, J Lycke 1, S Jeansson 1, L Rymo 1, M H Kaplan 1, A Vahlne 1
PMCID: PMC51956  PMID: 1712105

Abstract

Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 of HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.

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Selected References

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