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. 1991 Jul 1;88(13):5829–5831. doi: 10.1073/pnas.88.13.5829

Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.

J Prichard 1, D Rothman 1, E Novotny 1, O Petroff 1, T Kuwabara 1, M Avison 1, A Howseman 1, C Hanstock 1, R Shulman 1
PMCID: PMC51971  PMID: 2062861

Abstract

Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.

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Selected References

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