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. 1991 Jul 1;88(13):5917–5921. doi: 10.1073/pnas.88.13.5917

Population dynamics of natural antibodies in normal and autoimmune individuals.

F Varela 1, A Andersson 1, G Dietrich 1, A Sundblad 1, D Holmberg 1, M Kazatchkine 1, A Coutinho 1
PMCID: PMC51989  PMID: 2062870

Abstract

We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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