MEDICAL SCIENCES Retraction for “Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging,” by Tina Wenz, Susana G. Rossi, Richard L. Rotundo, Bruce M. Spiegelman and Carlos T. Moraes, which appeared in issue 48, December 1, 2009, of Proc Natl Acad Sci USA (106:20405–20410; first published November 16, 2009; 10.1073/pnas.0911570106).
The authors wish to note the following, “This article describes improved systemic health in mice overexpressing PGC-1α in muscle. Following an investigation on Tina Wenz by the University of Cologne, it was concluded that there was scientific misconduct with respect to the above paper. Specifically, blots in Figs. 2D and 3B also appear in an unrelated publication (1). In addition, there was a previously detected duplication of a tubulin blot between Figs. 4D and 5D. Even if its main conclusions may be correct, given that the scientific integrity of the paper was compromised, we see the retraction of the paper as the best corrective action. We sincerely apologize to the scientific community.”
1. Noe N, et al. (2013) Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. Mitochondrion 13(5):417–426.