Changes in brown adipose tissue (BAT) volume, activity, and maximum standardized uptake value (SUVmax) in individual subjects measured after 120 minutes of cold exposure (15–16°C) in the hypothyroid state and then in the thyrotoxic state. (A) Brown fat 18F-fluorodeoxyglucose (FDG) uptake in a study subject (53 years old, female, body mass index 19.6 kg/m2) illustrated using coronal representations of positron emission tomography in the hypothyroid state (TSH = 70.90 μIU/mL) and then in the thyrotoxic state (TSH = 0.03 μIU/mL), the black arrows pointing to the right and left supraclavicular BAT depots. (B) Changes in BAT volume. (C) Changes in BAT activity. (D) Changes in BAT SUVmax.