J Cancer Prev 2016;21:187–193
https://doi.org/10.15430/JCP.2016.21.3.187
In Table 2 and 3, cutoff values of RANTES, ApoA2, TTR, Svcam-1 (and sensitivity and specificity values accordingly) were wrongly marked. This is not an analytical error, so the main results and conclusion should not be affected by the correction.
Table 2.
Comparison of AUC values of training data set for single/combined marker(s) using logistic regression
| Marker | AUC | Probability | Sensitivity at 94% specificity (%) | Cutoff at 94% specificity |
|---|---|---|---|---|
| HE4 | 0.821 | 5.04E-51 | 51.43 | 0.1094199 |
| CEA | 0.753 | 1.78E-32 | 33.21 | 0.6434527 |
| RANTES | 0.858 | 1.02E-62 | 61.79 | 4.67369 |
| ApoA2 | 0.867 | 4.98E-66 | 61.07 | 5.350998 |
| TTR | 0.83 | 1.20E-53 | 46.07 | 5.374748 |
| Svcam-1 | 0.552 | 0.0074418 | 13.93 | 2.881887 |
| CEA, HE4 | 0.855 | 6.12E-62 | 55.00 | 0.5850375 |
| RANTES, ApoA2, TTR, Svcam-1 | 0.964 | 2.88E-104 | 84.29 | 0.4779614 |
| CEA, HE4, RANTES, ApoA2, TTR, Svcam-1 | 0.983 | 2.03E-112 | 92.50 | 0.357278 |
| CEA, HE4, RANTES, ApoA2, TTR, Svcam-1, age | 0.986 | 3.68E-114 | 93.21 | 0.3700928 |
AUC, the area under the curve; HE4, human epididymis secretory protein 4; CEA, carcinoembryonic antigen; RANTES, regulated on activation, normal T cell expressed and secreted; ApoA2, apolipoprotein A2; TTR, transthyretin; sVCAM-1, secretory vascular cell adhesion molecule-1.
Table 3.
Comparison of AUC values of test data set for single/combined marker(s) using logistic regression
| Marker | AUC | Probability | Cutoff from training | Specificity at the cutoff (%) | Sensitivity at the cutoff (%) |
|---|---|---|---|---|---|
| HE4 | 0.842 | 2.25E-13 | 0.1094199 | 89.33 | 57.53 |
| CEA | 0.681 | 6.60E-05 | 0.6434527 | 94.67 | 28.77 |
| RANTES | 0.829 | 1.83E-12 | 4.67369 | 90.67 | 58.67 |
| ApoA2 | 0.828 | 1.97E-12 | 5.350998 | 90.67 | 46.67 |
| TTR | 0.791 | 3.89E-10 | 5.374748 | 94.67 | 44.00 |
| Svcam-1 | 0.698 | 1.48E-05 | 2.881887 | 94.67 | 14.67 |
| CEA, HE4 | 0.841 | 2.66E-13 | 0.5850375 | 86.67 | 57.33 |
| RANTES, ApoA2, TTR, Svcam-1 | 0.942 | 4.47E-21 | 0.4779614 | 89.33 | 77.33 |
| CEA, HE4, RANTES, ApoA2, TTR, Svcam-1 | 0.985 | 5.26E-25 | 0.357278 | 90.67 | 94.67 |
| CEA, HE4, RANTES, ApoA2, TTR, Svcam-1, age | 0.988 | 2.71E-25 | 0.3700928 | 93.33 | 92.00 |
AUC, the area under the curve; HE4, human epididymis secretory protein 4; CEA, carcinoembryonic antigen; RANTES, regulated on activation, normal T cell expressed and secreted; ApoA2, apolipoprotein A2; TTR, transthyretin; sVCAM-1, secretory vascular cell adhesion molecule-1.