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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1991 Aug 1;88(15):6501–6505. doi: 10.1073/pnas.88.15.6501

Error filtration, interference, and the human linkage map.

D C Shields 1, A Collins 1, K H Buetow 1, N E Morton 1
PMCID: PMC52113  PMID: 1862077

Abstract

Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dracopoli N. C., O'Connell P., Elsner T. I., Lalouel J. M., White R. L., Buetow K. H., Nishimura D. Y., Murray J. C., Helms C., Mishra S. K. The CEPH consortium linkage map of human chromosome 1. Genomics. 1991 Apr;9(4):686–700. doi: 10.1016/0888-7543(91)90362-i. [DOI] [PubMed] [Google Scholar]
  2. Keats B. J., Sherman S. L., Morton N. E., Robson E. B., Buetow K. H., Cartwright P. E., Chakravarti A., Francke U., Green P. P., Ott J. Guidelines for human linkage maps. An International System for Human Linkage Maps (ISLM, 1990). Ann Hum Genet. 1991 Jan;55(Pt 1):1–6. doi: 10.1111/j.1469-1809.1991.tb00392.x. [DOI] [PubMed] [Google Scholar]
  3. Keats B. J., Sherman S. L., Morton N. E., Robson E. B., Buetow K. H., Cartwright P. E., Chakravarti A., Francke U., Green P. P., Ott J. Guidelines for human linkage maps: an international system for human linkage maps (ISLM, 1990). Genomics. 1991 Mar;9(3):557–560. doi: 10.1016/0888-7543(91)90426-f. [DOI] [PubMed] [Google Scholar]
  4. LANE P. W. WHIRLER MICE: A RECESSIVE BEHAVIOR MUTATION IN LINKAGE GROUP VIII. J Hered. 1963 Nov-Dec;54:263–266. doi: 10.1093/oxfordjournals.jhered.a107262. [DOI] [PubMed] [Google Scholar]
  5. Lander E. S., Green P. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363–2367. doi: 10.1073/pnas.84.8.2363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Liberman U., Karlin S. Theoretical models of genetic map functions. Theor Popul Biol. 1984 Jun;25(3):331–346. doi: 10.1016/0040-5809(84)90013-3. [DOI] [PubMed] [Google Scholar]
  8. MORTON N. E. Sequential tests for the detection of linkage. Am J Hum Genet. 1955 Sep;7(3):277–318. [PMC free article] [PubMed] [Google Scholar]
  9. Morton N. E., Andrews V. MAP, an expert system for multiple pairwise linkage analysis. Ann Hum Genet. 1989 Jul;53(Pt 3):263–269. doi: 10.1111/j.1469-1809.1989.tb01793.x. [DOI] [PubMed] [Google Scholar]
  10. Morton N. E., Collins A. Counting algorithms for linkage. Ann Hum Genet. 1990 May;54(Pt 2):103–106. doi: 10.1111/j.1469-1809.1990.tb00365.x. [DOI] [PubMed] [Google Scholar]
  11. Morton N. E., Collins A. Standard maps of chromosome 10. Ann Hum Genet. 1990 Jul;54(Pt 3):235–251. doi: 10.1111/j.1469-1809.1990.tb00381.x. [DOI] [PubMed] [Google Scholar]
  12. Morton N. E., MacLean C. J., Lew R. Tests of hypotheses on recombination frequencies. Genet Res. 1985 Jun;45(3):279–286. doi: 10.1017/s0016672300022266. [DOI] [PubMed] [Google Scholar]
  13. Olson M., Hood L., Cantor C., Botstein D. A common language for physical mapping of the human genome. Science. 1989 Sep 29;245(4925):1434–1435. doi: 10.1126/science.2781285. [DOI] [PubMed] [Google Scholar]
  14. Rao D. C., Keats B. J., Lalouel J. M., Morton N. E., Yee S. A maximum likelihood map of chromosome 1. Am J Hum Genet. 1979 Nov;31(6):680–696. [PMC free article] [PubMed] [Google Scholar]
  15. Rao D. C., Morton N. E., Lindsten J., Hultén M., Yee S. A mapping function for man. Hum Hered. 1977;27(2):99–104. doi: 10.1159/000152856. [DOI] [PubMed] [Google Scholar]

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