| 1964 | John Eager Howard, M.D. Urinary Stone. |
| 1965 | Grant W. Liddle, M.D. Analyse Circadian Rhythms of Adrenal Secretions. |
| 1966 | John P. Merrill, M.D. What Can We Do for the Patient with Renal Failure? |
| 1967 | Steward Wolf, M.D. Neural Mechanisms in Sudden Cardiac Death |
| 1968 | Robert W. Wilkins, M.D. Clinical and Climatological Observations of Hypertension. |
| 1969 | James B. Wyngaarden, M.D. The Pathophysiology of Hyperuricemia in Gout. |
| 1970 | A. McGehee Harvey, M.D. Myasthenia Gravis—The First 100 Years of Perspective. |
| 1971 | Marvin D. Siperstein, M.D., Ph.D. The Relationship of Cholesterol Biosynthesis to Cancer. |
| 1972 George F. Cahill, Jr., M.D. Ketosis. | |
| 1973 | Richard B. Hornick, M.D. Salmonella Infections—Newer Perspectives of an Old Infection. |
| 1974 | Jacques Genest, M.D. The Renin-Angiotensin System. |
| 1975 | Victor A. McKusick, M.D. New Genetic Insight into Old Diseases. |
| 1976 | Robert M. Bird, M.D. Information Transfer in the Service of Medicine. |
| 1977 | Robert Austrian, M.D. of Gold and Pneumococci. |
| 1978 | Carl W. Gottschalk, M.D. The Nephrons in Bright’s Disease: Their Structure and Function. |
| 1979 | Sheldon M. Wolff, M.D. The Pathogenesis of Fever in Human Subjects. |
| 1980 | Charles C. J. Carpenter, M.D. Myths, Mandarins and Molecules: The Cautionary Tale of Cholera. |
| 1981 | Leighton E. Cluff, M.D. The Climate of Patient Care and Medical Education. |
| 1982 | Daniel D. Federman, M.D. The Determinants of Human Sexuality. |
| 1983 | Purnell W. Choppin, M.D. Membrane Proteins and Virus Virulence. |
| 1984 | Jack M. Gwaltney, Jr., M.D. Climatology and the Common Cold. |
| 1985 | Louis Tobian, M.D. High Potassium Diets Strongly Protect Against Stroke Deaths and Renal Disease: A Possible Legacy from Prehistoric Man. |
| 1986 | Richard S. Ross, M.D. Thrombolysis and Dilatation in Coronary Occlusion. |
| 1987 | William N. Kelley, M.D. and Thomas D. Palella, M.D. Current Status of Human Gene Therapy. |
| 1988 | John A. Oates, M.D. Participation of Eicosanoids in the Syndromes of Myocardial Ischemia. |
| 1989 | David G. Nathan, M.D. The Regulation of Hematopoiesis by Growth Factors. |
| 1990 | Michel Chrétien, O.C., M.D. From POMC to Functional Diversity of Neural Peptides: The Key Importance of Convertases. |
| 1991 | Gerald L. Mandell, M.D. Microbial Defenses Against Killing by Phagocytes. |
| 1992 | Jeremiah A. Barondess, M.D. The Future of Generalism. |
| 1993 | John D. Stobo, M.D. Academic Health Centers: Change Agents for Health Care Reform. |
| 1994 | J. Claude Bennett, M.D. Academic Medicine: Building on the Strengths of the Past as We Approach a Cloudy Future. |
| 1995 | Stuart Bondurant, M.D. On the Climate of the City. |
| 1996 | Edward W. Hook, M.D. Humanities in Medicine: Treatment of a Deficiency Disorder. |
| 1997 | R. Gordon Douglas, Jr., M.D. Vaccine Prophylaxis Today: It’s Science, Application and Politics. |
| 1998 | James R. Gavin, III. Academe Confronts a Future of Growing Diversity: Will We Lead or Will We Follow? |
| 1999 | John Mendelsohn, M.D. Targeted Cancer Therapy. |
| 2000 | Ralph L. Nachman, M.D. Hypercoagulable States: Challenges and Opportunities. |
| 2001 | Jared J. Grantham, M.D. Polycystic Kidney Disease: Old Disease in a New Context. |
| 2002 | R. Wayne Alexander, M.D., Ph.D. Pathogenesis of Atherosclerosis: Redox As a Unifying Mechanism. |
| 2003 | Merle A. Sande, M.D., MACP The Terrible Impact of AIDS on Africa—The Case for Prevention & Treatment Now. |
| 2004 | C. Richard Conti, M.D. The Evolution of Management of Acute Coronary Syndromes. |
| 2005 | John G. Bartlett, M.D. Avian Influenza. |
| 2006 | James A. Fagan, M.D. Intelligent Design of Cancer Therapy: Trials and Tribulations. |
| 2007 | Stephen B. Greenberg. Osler-Web-Rendezvous: Impact of the Information Explosion on Medical Education. |
| 2008 | Katherine A. High, M.D. Gene Therapy for Inherited Disorders: From Christmas Disease to Leber’s Amaurosis |
| 2009 | Eric G. Neilson, M.D. The Origin of Fibroblasts and the Terminality of Epithelial Differentiation |
| 2010 | Antonio M. Gotto, M.D. Cholesterol, Inflammation and Cardiovascular Disease: Is It All LDL? |
| 2011 | Martin JL. Blaser, M.D. Global Warming Redux: The Disappearing Microbiota and Epidemic Obesity |
| 2012 | Nancy J. Brown, M.D. Developing Physician-Scientists: A perspective |
| 2013 | Christopher Plowe, M.D. New Additions to the Toolbox for Glosbal Malaria Eradication. |
| 2014 | Raymond N. Dubois, M.D., Ph.D. Inflammation, Immune Modulators and Chronic Disease. |
| 2015 | Anne A. Gershon, M.D., and Michael D. Gershon, M.D. Varicella Zoster Virus: From Outside to Inside. |
. 2016;127:280–281.