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. 2016 May 31;7(29):45429–45443. doi: 10.18632/oncotarget.9742

Figure 1. Pro-apoptotic activity of bortezomib, the P-SII G5 and its pro-drug derivative 2cPE in primary B-CLL cells.

Figure 1

A. Primary B-CLL cells viability following treatment with escalating doses of G5 or bortezomib for 24 hours as indicated. Cell viability was calculated as percentage of cells negative to PI and Annexin V staining after cytofluorimetric analysis. B. Flow cytometry analysis for apoptotic markers (Annexin V/PI) in order to define the type of cell death. Primary B-CLL cells were treated with the indicated concentrations of bortezomib or G5 for 24 hours. C. Primary B-CLL cells viability following treatment with escalating doses of 2cPE for 24 hours as indicated. Cell viability was calculated as the percentage of cells negative to PI and Annexin V staining after cytofluorimetric analysis. D. Flow cytometry analysis for apoptotic markers (Annexin V/PI) in order to define the type of cell death. Primary B-CLL cells were treated with the indicated concentrations of 2cPE for 24 hours. Columns, mean loss of viability + SD. *=p<0.05; **=p<0.01; ***p=<0.005.