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. 2016 May 31;7(29):45429–45443. doi: 10.18632/oncotarget.9742

Figure 4. Interfering with the different adaptive responses elicited by 2cPE augmented the apoptotic response.

Figure 4

A. MEC-1 cells were pre-treated with the indicated concentrations (μM) of BSO, for 24 h. Next, 2cPE (1μM), DMNQ (20μM) were added for further 24 h. B. MEC-1 cells were pre-treated with the indicated concentrations (μM) of 17-AAG for 1 h. Next, 2cPE (1μM), bortezomib (0.5 μM) were added for further 24 h. C. MEC-1 cells were pre-treated with the indicated concentrations (μM) of LCKi for 16 h. Next, 2cPE (1μM), bortezomib (0.5 μM) were added for further 24 h. Cell death was scored by PI staining using cytofluorimetric analysis and caspase activity was measured in parallel. Columns, mean (n = 3); bars, SD. *=p<0.05; **=p<0.01; ***p=<0.005.