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. 2016 Jun 14;7(29):45584–45596. doi: 10.18632/oncotarget.10052

Figure 5. Discovery of new miRNAs mediating treatment responses for tamoxifen and metformin in MCF-7 or MDA-MB-231 cell lines via qRT-PCR assays.

Figure 5

(A) The qRT-PCR assay for expression change of 6 predicted miRNAs among the top 10 predicted candidates in the MCF-7 cells treated with 100 nM, 500 nM or 1 μM tamoxifen respectively. (B) The qRT-PCR assay for expression change for 11 predicted miRNAs among the top 20 predicted candidates in the MCF-7 cells treated with 1 mM, 5 mM or 10 mM metformin respectively. (C) The qRT-PCR assay for expression change of 12 predicted miRNAs among the top 20 predicted candidates in the MDA-MB-231 cells treated with 1 mM, 5 mM or 10 mM metformin respectively. *p < 0.05, **p < 0.01 and ***p < 0.001 were determined by t-test. Error bars represent standard errors (s.d., n = 3).