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. 2016 Jun 30;7(30):48027–48037. doi: 10.18632/oncotarget.10338

Figure 1. Dragon-overexpression induces the resistance of colon cancer cells to oxaliplatin in vitro.

Figure 1

(A and B) Expression of Dragon in Dragon-overexpressing CMT93 and HCT116 cells. Control (pLV or nc-pLV) and Dragon-overexpressing (oeD or oe-Dra) CMT93 and HCT116 cells were lysed to examine Dragon protein expression by Western blot analysis (A) and Dragon mRNA expression by qRT-PCR (B). GAPDH was used as a control. (C) Effect of Dragon overexpression on the viability and growth rate of CMT93 cells cultured in the presence of oxaliplatin. CCK8 assays were used to determine the viability (left panel) and growth inhibition rate (right panel) of control and Dragon-overexpressing CMT93 cells in the presence of increasing doses of oxaliplatin. (D) Effect of Dragon overexpression on the viability (left panel) and growth rate (right panel) of HCT116 cells in the presence of oxaliplatin. *P < 0.05 and **P < 0.01.