Table 1.
List of identified proteins that exhibit a significantly reduced concentration in crude mdx-4cv hind limb muscle preparations as revealed by label-free LC-MS/MS analysis.
| Accession No. | Protein Name | Unique Peptides | Confidence Score | Anova (p) | Fold Change |
|---|---|---|---|---|---|
| P11531 | Dystrophin Dp427 | 9 | 457.7 | 0.000053 | −14.61 |
| Q8VCT4 | Carboxylesterase 1D | 4 | 175.0 | 0.001943 | −5.85 |
| O55137 | Acyl-coenzyme A thioesterase 1 | 2 | 139.31 | 0.002283 | −4.35 |
| P19096 | Fatty acid synthase | 3 | 198.37 | 0.006235 | −3.99 |
| Q9JJW5 | Myozenin-2 | 2 | 67.3 | 0.016575 | −3.98 |
| Q8C0M9 | Isoaspartyl peptidase/L-asparaginase | 3 | 202.6 | 0.000870 | −3.97 |
| P97823 | Acyl-protein thioesterase 1 | 2 | 115.7 | 0.017276 | −3.96 |
| P32848 | Parvalbumin alpha | 4 | 262.0 | 0.040028 | −3.94 |
| Q61234 | Alpha-1-syntrophin | 3 | 101.6 | 0.000873 | −3.68 |
| P51667 | Myosin regulatory light chain MLC2, slow | 6 | 319.1 | 0.029470 | −3.64 |
| Q08642 | Protein-arginine deiminase type-2 | 10 | 498.3 | 0.003334 | −3.55 |
| P09542 | Myosin light chain MLC3 | 8 | 548.5 | 0.016031 | −3.50 |
| P16015 | Carbonic anhydrase CA3 | 21 | 1652.1 | 0.001537 | −3.43 |
| Q8QZS1 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial | 3 | 202.7 | 0.002445 | −3.14 |
| Q64105 | Sepiapterin reductase | 7 | 515.0 | 0.002035 | −3.14 |
| P70695 | Fructose-1,6-bisphosphatase isozyme 2 | 9 | 592.7 | 0.003223 | −3.09 |
| Q9DAK9 | 14 kDa phosphohistidine phosphatase | 2 | 208.6 | 0.000263 | −3.01 |
| P04247 | Myoglobin | 16 | 1768.3 | 0.000652 | −2.93 |
| Q8BVI4 | Dihydropteridine reductase | 5 | 336.0 | 0.000315 | −2.91 |
| Q9DBB8 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 2 | 119.5 | 0.026280 | −2.90 |
| Q9D358 | Low molecular weight phosphotyrosine protein phosphatase | 2 | 115.6 | 0.002473 | −2.89 |
| P06801 | NADP-dependent malic enzyme | 8 | 348.2 | 0.005720 | −2.84 |
| P21107 | Tropomyosin alpha-3 chain | 3 | 113.6 | 0.024475 | −2.71 |
| O55103 | Periaxin | 2 | 50.9 | 0.014583 | −2.66 |
| Q8R1G2 | Carboxymethylenebutenolidase homolog | 4 | 418.4 | 0.005828 | −2.64 |
| Q9D0K2 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | 2 | 143.4 | 0.009917 | −2.60 |
| Q9WUZ5 | Troponin I, slow skeletal muscle | 2 | 114.0 | 0.033414 | −2.50 |
| P56375 | Acylphosphatase-2 | 3 | 227.8 | 0.000551 | −2.39 |
| P17563 | Selenium-binding protein 1 | 7 | 398.9 | 0.000733 | −2.35 |
| P14152 | Malate dehydrogenase, cytoplasmic | 8 | 588.6 | 0.000441 | −2.33 |
| Q9CRB9 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial | 2 | 191.9 | 0.008307 | −2.28 |
| P70349 | Histidine triad nucleotide-binding protein 1 | 6 | 504.1 | 0.004703 | −2.27 |
| P11404 | Fatty acid-binding protein, FABP3, heart | 5 | 407.2 | 0.011413 | −2.21 |
| Q01768 | Nucleoside diphosphate kinase B | 3 | 216.1 | 0.029418 | −2.21 |
| Q9D0S9 | Histidine triad nucleotide-binding protein 2, mitochondrial | 2 | 88.7 | 0.007985 | −2.14 |
| Q9CQR4 | Acyl-coenzyme A thioesterase 13 | 2 | 155.3 | 0.009677 | −2.14 |
| P15626 | Glutathione S-transferase Mu 2 | 5 | 300.4 | 0.019473 | −2.13 |
| P08228 | Superoxide dismutase [Cu-Zn] | 5 | 205.9 | 0.004575 | −2.08 |
| Q8BZA9 | Fructose-2,6-bisphosphatase (TIGAR) | 2 | 106.5 | 0.003999 | −2.08 |
| Q91ZJ5 | UTP-glucose-1-phosphate uridylyltransferase | 15 | 949.2 | 0.002697 | −2.08 |
| P63017 | Heat shock cognate 71 kDa | 4 | 465.8 | 0.003124 | −2.03 |
| P15327 | Bisphosphoglycerate mutase | 3 | 213.3 | 0.013366 | −2.02 |
| Q60864 | Stress-induced-phosphoprotein 1 | 3 | 175.8 | 0.001854 | −2.01 |