Updated Priorities Among Effective Clinical Preventive Services

Abstract

PURPOSE

The Patient Protection and Affordable Care Act’s provisions for first-dollar coverage of evidence-based preventive services have reduced an important barrier to receipt of preventive care. Safety-net providers, however, still serve a substantial uninsured population, and clinician and patient time remain limited in all primary care settings. As a consequence, decision makers continue to set priorities to help focus their efforts. This report updates estimates of relative health impact and cost-effectiveness for evidence-based preventive services.

METHODS

We assessed the potential impact of 28 evidence-based clinical preventive services in terms of their cost-effectiveness and clinically preventable burden, as measured by quality-adjusted life years (QALYs) saved. Each service received 1 to 5 points on each of the 2 measures—cost-effectiveness and clinically preventable burden—for a total score ranging from 2 to 10. New microsimulation models were used to provide updated estimates of 12 of these services. Priorities for improving delivery rates were established by comparing the ranking with what is known of current delivery rates nationally.

RESULTS

The 3 highest-ranking services, each with a total score of 10, are immunizing children, counseling to prevent tobacco initiation among youth, and tobacco-use screening and brief intervention to encourage cessation among adults. Greatest population health improvement could be obtained from increasing utilization of clinical preventive services that address tobacco use, obesity-related behaviors, and alcohol misuse, as well as colorectal cancer screening and influenza vaccinations.

CONCLUSIONS

This study identifies high-priority preventive services and should help decision makers select which services to emphasize in quality-improvement initiatives.

INTRODUCTION

The landscape for prevention in primary care has changed dramatically since the Committee on Clinical Preventive Service Priorities published the first ranking of clinical preventive services in 2001,¹ and the National Commission on Prevention Priorities (NCPP) last updated the list in 2006.² A growing evidence base has expanded knowledge about effective preventive services. At the same time, the Patient Protection and Affordable Care Act (ACA) and the pursuit of the Triple Aim³ seek to expand access to and the efficiency of primary care.

Changes in primary care have potential to improve utilization of preventive services. Patient-centered medical homes (PCMHs) have been associated with increased use of preventive services, though it is not clear whether health and financial outcomes are affected.^4–6 Accountable Care Organizations (ACOs), when combined with PCMHs, may empower primary care and incentivize change,⁷ and ACO shared-savings contracts may encourage hospital systems and specialty providers to become vested stakeholders in evidence-based prevention. Preventive care quality measures and incentives in ACO contracts might assure that prevention is prioritized while participants pursue strategies to reduce the cost of care.

Since the release of the 2001 clinical preventive services ranking, the National Committee for Quality Assurance more than doubled the Healthcare Effectiveness Data and Information Set measures in primary and secondary prevention.⁸ In 2013, the committee adopted these quality measures for ACOs, which include 9 measures for primary prevention and screening.⁹ In 2014 and 2015, it introduced measures to track unnecessary cervical cancer screening in adolescent females and unnecessary prostate cancer screening in older men, with the goal of reducing utilization and preventing harm.^8,10

The ACA now mandates first-dollar coverage for evidence-based prevention in nongrandfathered plans,¹¹ including grade A and B recommendations of the US Preventive Services Task Force (USPSTF). Evidence of increased utilization of preventive services associated with implementation of the ACA is beginning to emerge, particularly among persons aged 19 to 25 years as covered dependents in family insurance policies. Nearly 1 million additional women have received human papillomavirus vaccinations¹² through expanded insurance coverage. From 2009 to 2011, hypertension screening, cholesterol screening, and annual dental visits increased among young adults, though influenza vaccinations did not.¹³ Early data hint at increased receipt of other preventive services for adults of all ages^14,15 as ACA provisions for expanded insurance coverage and no co-payments took effect.

Meanwhile, new knowledge is changing preventive service recommendations, which may alter our understanding of which services may produce highest value relative to each other. In the past decade, the Advisory Committee on Immunization Practices recommended hepatitis A and rotavirus immunizations for children, human papillomavirus and meningococcal immunizations for adolescents, influenza vaccinations for an expanded population to include all ages above 6 months, herpes zoster vaccine to prevent shingles in older adults, and the additional vaccines of both the tetanus-diphtheria booster and pneumococcal vaccinations for adults. In the same time frame, the USPSTF recommended new services or substantially expanded the recommended target population for 13 evidence-based preventive services while retiring 3 recommendations. The value of other recommended services may be affected by new technologies or new use of existing technologies, including human papillomavirus testing in conjunction with Papanicolaou screening, improvements in testing for human immunodeficiency virus, and offering varenicline to help smokers to quit.

In creating an updated priority list of evidence-based preventive services, we incorporated many of these new and revised recommended clinical preventive services to assist clinicians and other decision makers in their efforts to plan quality improvement initiatives, develop performance measurements, build primary care medical homes, and incorporate preventive services into ACO contracts.

METHODS

Methods were guided by the NCPP, a panel of health care clinicians, health insurance plan leaders, employers, government representatives, and academics. HealthPartners Institute conducted the analytical work.

Included Preventive Services

The clinical preventive services considered for this update included services recommended by the USPSTF for the general population that were given an A or B grade, Advisory Committee on Immunization Practices recommendations for the general population, and services recommended by the USPSTF for those at increased risk for cardiovascular disease (CVD) or sexually transmitted infections that were given an A or B grade. Services for the general population were defined as those for which the recommended population is limited only by age or sex criteria. Services that are routinely co-occurring, such as childhood vaccines, were evaluated as 1 service. For a more complete description of included and excluded services, see the Supplemental Appendix, available at http://www.annfammed.org/content/15/1/14/suppl/DC1.

Measures and Estimation

Preventive services were evaluated using 2 measures: clinically preventable burden as a measure of the health impact of a preventive service, and cost-effectiveness as a measure of efficiency. Clinically preventable burden is defined here as the total quality-adjusted life years (QALYs) that could be gained if the clinical preventive service were delivered at recommended intervals to a US birth cohort of 4 million patients over the years of life for which a service was recommended. Cost-effectiveness is the net cost per QALY gained. Estimation methods have been previously reported.¹⁶ Here we highlight new methods as well as methods that are key to interpreting results.

Using simulation models, the clinically preventable burden and cost-effectiveness were computed by comparing scenarios with no utilization of a service with a scenario in which the service was offered to 100% of the target population. The current burden of cervical cancer is low compared with what it would be without cervical cancer screening, as is the current burden of vaccine-preventable childhood infectious diseases. The total health benefit as calculated by clinically preventable burden in this manner reveals the overall importance of such services.

The clinically preventable burden and cost-effectiveness estimates reflect scenarios with 100% of the target population offered each service, but not all accept or complete follow-up diagnostic testing, treatment, medication use, or behavior change necessary to benefit from the service. Realistic estimates of adherence were used to allow clinically preventable burden estimates to reflect differences in patient follow-through.

The literature for some services, such as mammography screening, provides data on the effectiveness of periodic utilization, and the literature for other services, such as tobacco cessation counseling, focuses on one-time use. Clinically preventable burden and cost-effectiveness are estimated with greater consistency across services through the use of modeling to estimate the cumulative benefit of multiple opportunities to utilize the service throughout the recommended age range. Clinically preventable burden and cost-effectiveness estimates reflect the impact of each service throughout the lifetime, including the delayed impact after the age when the service is no longer routinely offered.

QALYs are not discounted to present value in calculating clinically preventable burden; costs and QALYs, however, were discounted by 3% per year in the cost-effectiveness ratio. Costs are either measured in or adjusted to 2012 US dollars.

In estimating cost-effectiveness, the principles of the reference case methods of the first Panel on Cost Effectiveness in Health and Medicine were followed to promote consistency with recognized best practices and consistency across services.¹⁷ In keeping with these methods, costs include quantitatively important medical costs for screening, counseling, pharmaceutical treatment, and follow-up diagnostic tests and treatments for both true- and false-positive screening findings. The value of a patient’s time required to travel to the appointment and receive both the preventive service and needed follow-up was calculated using average hourly earnings for the United States.¹⁸ For visits in which more than the preventive service would be addressed, a fraction of a 15-minute office visit and associated travel time were apportioned to the cost of the service. Potential savings included medical costs for avoided treatments or reduced costs for less-intensive, earlier-stage treatments. In keeping with the principles of the reference case methods,¹⁷ savings do not reflect potential productivity gains when using health utilities to calculate QALYs, because the health utilities may already reflect patient valuation of time lost.

New in this ranking is the use of HealthPartners Institute’s ModelHealth microsimulation models to provide more precise estimates for preventive services with complex time elements, such as cancer screenings, CVD screenings, and repeated counseling related to diet, physical activity, and tobacco use. The microsimulation models tracked 500,000 or more simulated individuals in annual cycles over their lifetimes, both in scenarios with zero utilization and offering the preventive service to 100% of the target population. Twelve services in the ranking were estimated using microsimulation. Five of these are exemplified in the two accompanying articles on tobacco counseling and reducing other CVD risks. Other services were estimated either with spreadsheet models (13 services) or using existing peer-reviewed literature (3 services). The spreadsheet models assess the impact on a birth cohort as a whole over discrete age groups rather than by simulating individuals and tracking their status and outcomes year-by-year, as done in the microsimulation models. Literature-based estimates require adjustments to reported results to improve consistency across services in the ranking, such as inflation adjustment, adding time costs for receipt of preventive services, and calculations to convert the impact of a cross-sectional analysis to a birth cohort. Spreadsheet-based estimates often rely heavily on multiple published studies; therefore, spreadsheet and literature-based estimates represent a continuum of new calculations and use of modeled estimates from others. For example, our estimate for childhood immunizations—a literature-based estimate—uses model estimates from 2 other studies of the events prevented¹⁹ and the cost-savings,²⁰ but uses information from additional sources to estimate QALYs saved and the costs of the vaccination series. Summaries of the methods for services are available online.²¹

Service Scoring

As with the prior ranking, the NCPP chose to group services with a similar clinically preventable burden or cost-effectiveness into 5 scoring categories for each measure to balance the goal of delineated services on value with the risk of overstating the precision of the estimates.²² Services were sorted in descending order of burden estimates and in ascending order of cost-effectiveness ratios. The 28 included services are not divisible into 5 equally sized groups; therefore, for each metric we identified groups of 5 and 6 services that maximized the percentage difference between estimates of the lowest estimate in the higher scoring category and the highest estimate in the lower scoring category. Services in the highest group were assigned a score of 5, and services in the lowest group were assigned a score of 1. Scores for clinically preventable burden and cost-effectiveness were then added to give each service a score ranging from 10 (best) to 2 (lowest).

Sensitivity analysis was conducted for each estimate and used to indicate which services had scores with greater uncertainty.

Marginal Effects

The marginal clinically preventable burden of increasing utilization from current levels to 90% is provided as a supplemental result to help guide decision making to increase utilization. Patients receiving services may have risk profiles different from those who are not. Our estimates of marginal clinically preventable burden assume, however, that those currently not receiving services have the same baseline risk as those who are receiving services, because existing data are insufficient to quantify the association between known differences in population characteristics and disease risks.

RESULTS

The ranges of base case estimates for clinically preventable burden and cost-effectiveness that define the scoring ranges are displayed in Table 1. In Table 2 services are sorted by total score and alphabetically among services with the same total score. Six cost-saving services were all assigned a cost-effectiveness score of 5. Of these services, the childhood immunization series, counseling to discourage tobacco initiation among youth, and counseling to encourage tobacco cessation among adults also received the highest clinically preventive burden score of 5 and, therefore, had the highest possible total score of 10. Two other cost-saving services—alcohol misuse screening with brief intervention, and counseling on low-dose aspirin use—had clinically preventable burden scores of 3, giving them total scores of 8. Two cancer screening services, to prevent cervical and colorectal cancer, also received scores of 8.

Table 1.

Scoring Ranges

Score	CPBa Range: QALYb Saved, Undiscounted	CEc Range: $/QALY Saved, Discounted
5	>700,000	Cost-saving
4	190,000–700,000	0–3,500
3	70,000–190,000	33,500–50,000
2	18,000–70,000	50,000–75,000
1	<18,000	>75,000

CE = cost-effectiveness; CPB = clinically preventable burden; QALY = quality-adjusted life year.

^aA measure of the health impact of a preventive service.

^bYears saved if the clinical preventive services were delivered at recommended intervals to a US birth cohort of 4 million patients during the years of life for which a service was recommend.

^cMeasure of efficiency of the service in producing health improvement.

Table 2.

Priorities for Improving Utilization of Clinical Preventive Services

Services (Short Name)	Description	CPB	CE	Total
Childhood immunization series	ACIP childhood immunization seriesa	5	5	10
Tobacco use, brief prevention counseling, youth	Provide interventions to prevent initiation, including education or brief counseling	5	5	10
Tobacco use screening and brief counseling, adults	Screen adults for tobacco use and provide brief cessation counseling and pharmacotherapy	5	5	10
Alcohol misuse screening and brief intervention	Screen adults’ misuse and provide brief counseling to reduce alcohol use	3	5	8b
Aspirin chemoprevention for those at higher risk of CVD	Low-dose aspirin use for primary prevention of CVD in adults ages 50–59 y with ≤10%, 10-y CVD risk and other factors	3	5	8
Cervical cancer screening	Screen for cervical cancer in women aged 21 to 65 y with cytology (Papanicolaou smear) every 3 y	4	4	8
Colorectal cancer screening	Screen adults aged 50–75 y routinely	4	4	8b
Chlamydia and gonorrhea screening	Screen for chlamydia and gonorrhea in sexually active women aged ≤24 y, and in older women at increased risk for infection	3	4	7b
Cholesterol screening	Screen routinely for lipid disorders men aged >35 y, and screen younger men and women of all ages who are at increased risk of CHD. Treat with lipid-lowering medications	4	3	7
Hypertension screening	Measure blood pressure routinely in all adults and treat with antihypertensive medication to prevent the incidence of CVD	4	3	7
AAA screening	Screen men aged 65–75 y who have ever smoked 1 time for abdominal aortic aneurysm, using ultrasonography	2	4	6b
Healthy diet and physical activity counseling for those at higher risk of CVD	Offer or refer adults who are overweight or obese with additional CVD risk factors to intensive behavioral counseling to promote healthful diet and physical activity	5	1	6
HIV screening	Screen for HIV infection in adolescents and adults aged 15 to 65 y. Frequency varies by risk level	2	4	6b
HPV immunization	Administer a 3-dose series of HPV vaccine to all girls aged 11–12 y	3	3	6
Influenza immunization, adults	Immunize all adults against influenza annually	4	2	6b
Obesity screening, adults	Screen all adults routinely for obesity. Refer patients with a BMI of ≥30 kg/m2 to intensive behavioral interventions	5	1	6b
Syphilis screening	Screen all persons at increased risk for syphilis infection	1	5	6
Vision screening, children	Screen children routinely between ages 3 and 5 y to detect amblyopia	2	4	6b
Breast cancer screening	Biennial mammography for women aged 50–74 y; screening before age 50 y an individual decision	3	2	5b
Depression screening, adolescents	Screen adolescents aged 12–18 y for depression with systems to assure accurate diagnosis, treatment, and follow-up	2	3	5b
Depression screening, adults	Screen adults for depression with systems to assure accurate diagnosis, treatment, and follow-up	3	2	5b
Obesity screening, children and adolescents	Screen children aged ≥6 y for obesity. Offer or refer obese children to comprehensive, intensive behavioral intervention	4	1	5
Pneumococcal immunization, adults	Immunize adults aged >65 y against pneumococcal disease with PCV13 and PPSV23	2	3	5b
Herpes zoster immunization	Single dose of vaccine for adults aged >60 y	1	3	4
Osteoporosis screening	Screen women aged >65 y and younger women whose fracture risk is equal to or greater than that of white women aged 65 y with no additional risk factors	2	2	4
Folic acid chemoprevention	Women planning or capable of pregnancy should take a daily supplement with 0.4–0.8 mg of folic acid	1	2	3
Meningococcal immunization	Single dose of quadrivalent vaccine recommended for children aged 11 to 12 y, with a booster at age 16 y	1	1	2
Tdap/Td booster	One time Tdap and Td booster every 10 y	1	1	2

AAA = abdominal aortic aneurysm; ACIP = Advisory Committee on Immunization Practices; BMI = body mass index; CE = cost-effectiveness; CHD = coronary heart disease; CPB = clinically preventable burden; CVD = cardiovascular disease; HIV = human immunodeficiency virus; HPV = human papillomavirus; PCV13 = pneumococcal conjugate vaccine—13 pneumococcal serotypes; PPSV23 = pneumococcal polysaccharide vaccine—23 pneumococcal serotypes; Td = tetanus, diphtheria; Tdap = tetanus, diphtheria, and pertussis.

^aEstimate includes all recommended vaccines up to 10 years of age (diphtheria, tetanus, pertussis; measles, mumps, rubella; inactivated polio virus; Hemophilus influenzae type b; hepatitis A; hepatitis B; varicella; pneumococcal conjugate; influenza; and rotavirus) plus influenza vaccination to age 18 years.

^bSensitivity analysis indicated that a change of score of 2 or more is possible.

Chlamydia and gonorrhea screening, cholesterol screening, and hypertension screening received scores of 7. Obesity screening and healthy diet counseling for those at higher risk for CVD also scored well, with a total score of 6 despite the relatively high expense for these intensive interventions, which limited their cost-effectiveness. Six other services received a score of 6, including 2 screening services for sexually transmitted infections, 2 immunizations, screening for the abdominal aortic aneurism in higher risk men, and vision screening for children.

In some cases, sensitivity analysis indicated that a service’s total score may differ by more than 1 point. This outcome might occur either because the base case estimates for both clinically preventable burden and cost-effectiveness are near the upper or lower boundary for their scoring category, or because the base-case estimates are particularly uncertain as a result of plausible alternative values for multiple influential variables in the models. These services are indicated by a footnote in Table 2, and specific notes on uncertainty are provided in Supplemental Appendix, Table 1, available at http://www.annfammed.org/content/15/1/14/suppl/DC1.

Estimates of the additional QALYs that could be saved if utilization for services with total scores of 5 or higher were increased to 90% are displayed in Table 3. Services with greater limitations in utilization data, as explained in the footnote to Table 3, are displayed at the bottom of the table and assigned a utilization rate of 50%. For these services, 50% likely overstates current utilization; therefore, the resulting estimate of additional QALYs that would be gained from increasing utilization to 90% may be conservative. Across the list, preventive services that address health behaviors—including alcohol misuse, diet, physical activity, and tobacco use—provide great opportunities to improve population health even while our estimates account for realistic levels of nonadherence with the targeted behavior changes.

Table 3.

QALYs Saved if Utilization Rates Increase Above Current Levels

Services (Short Name)a	Source	Currently Receiving Services Nationallyb %	Additional QALY Saved if Currently Receiving Services Increased to 90%c
Services with utilization data available
Tobacco use counseling to prevent initiation by youthd	Jamal23	20	530,000
Tobacco use screening and brief cessation intervention, adults	NCQA24 Jamal25 King26	50	460,000
Alcohol misuse screening, brief intervention	McKnight-Eily27	10	140,000
Colorectal cancer screening	CDC28	65	110,000
Influenza immunization, adults	CDC29	45	100,000
HPV immunizationd	Reagan-Steiner30	50	59,000
Breast cancer screening	NCHS31 CDC28	75	42,000
Chlamydia and gonorrhea screeningd	CDC32	40	39,000
HIV screening	Chandra33	20	32,000
Aspirin chemoprevention for those at higher risk of CVD	Williams34	50	30,000
Cervical cancer screening	NCHS31 CDC28	85	14,000
Vision screening, children	Kemper35	75	5,000
Pneumococcal immunization, adults	CDC28	70	4,000
Services with utilization data assigned at 50%
Obesity screening, adultse	Assigned	50	540,000
Healthy diet counseling for those at higher risk of CVDe	Assigned	50	300,000
Obesity screening, children and adolescentsd,e	Assigned	50	78,000
Depression screening, adultse	Assigned Farr36 Edwards37	50	45,000
AAA screeninge	Assigned Shreibati38	50	21,000
Depression screening, adolescentsd,e	Assigned	50	11,000
Syphilis screeninge	Assigned	50	2,000

AAA = abdominal aortic aneurysm; CDC = Centers for Disease Control and Prevention; CMS = Centers for Medicare & Medicaid Services; CPS = Community Preventive Services; CVD = cardiovascular disease; FDA = Food and Drug Administration; HIV = human immunodeficiency virus; HPV = human papillomavirus; QALY = quality-adjusted life years; USPSTF = US Preventive Services Task Force.

^aSee Table 2 for a description of each service. Childhood immunizations, hypertension screening, and cholesterol omitted from table because of current high utilization rates.

^bCurrent utilization rates rounded and reflect approximate average of male and female patients, across all relevant age-groups and other important groups for a service, such as groups at high and low risk for disease.

^cIndicates additional lifetime QALYs saved if 90% of a cohort of 4 million were offered service as recommended.

^dYouth services estimated based on a target of 90% of youth receiving service annually, although slightly less than 90% of adolescents aged 12–17 years saw a health care professional in 2012.

^eBased on limited utilization data. Utilization data were considered limited if existing information was difficult to use to quantify utilization rates and place an upper boundary more precise than 50%. Either utilization data are completely lacking or are available only for a population for which generalizability to US population is highly questionable, or the utilization measures available are poorly aligned with the preventive service as recommended by the USPSTF.

Traditionally underutilized services of colorectal cancer screening(despite trends in increasing utilization), influenza vaccination, and co-delivered chlamydia and gonorrhea screening also provide substantial opportunities to improve population health. Finally, although hypertension screening and cholesterol screening are not included in Table 3 because of high screening rates, increasing the use of antihypertensive and cholesterol-lowering drugs subsequent to screening remains an important opportunity to improve control and outcomes.

DISCUSSION

This updated ranking reflects changes in the evidence base and recommendations for clinical preventive services at a time of changes in primary care. Since its inception—and years before Berwick et al described the Triple Aim³—the NCPP has maintained an emphasis on value. Focusing on high-value clinical preventive services is one way clinicians and systems can deliver on the Triple Aim.

Since 2001 only 6 recommended preventive services changed their score by more than 1 point in our ranking (see the Supplemental Appendix). This finding should reassure clinicians and health care organizations that expend substantial energy and resources to incorporate the results of this ranking into quality improvement efforts. New to the top of the priority list is brief counseling to prevent tobacco initiation among youth. As with other services aimed at improving health behaviors, our model estimates indicate that the seemingly small success rate—measured by changing lifestyles of a small percentage of patients—has large long-term effects when the health behaviors have extensive health consequences. There remains substantial opportunity for primary care to improve population health through increasing the utilization of these evidence-based services.

In the 2006 ranking, increasing colorectal cancer screening rates stood out as an opportunity to improve health by increasing utilization. National screening rates for colorectal cancer have climbed markedly in the intervening years. Continued health gains are possible by further reducing the gap between colorectal cancer screening rates and screening rates for CVD risk factors and other cancers.

Individual clinicians, medical groups, and health systems should review preventive service utilization rates of the populations they serve to identify opportunities to reduce delivery gaps at the local level. By comparing local utilization rates to the ranking in Table 2, while accounting for age and risk characteristics of the populations they serve, local decision makers can identify their own opportunities for improving patients’ health. We also encourage decision makers to assess local disparities in utilization of high-priority services and tailor care processes to close gaps. Priorities may also vary at the individual patient characteristics, ³⁹ requiring clinician and patient judgment in defining individualized priorities.

Community-based organizations also have a role to play in closing gaps. For example, the Community Preventive Services Task Force in 2015 recommended implementing and maintaining school-based health centers in low-income communities. Several of those outcomes are relevant to the preventive services in this ranking, including increases in immunizations and reductions in tobacco smoking and alcohol use.⁴⁰ An integrated program that strategically combines the efforts of clinics and community-based organizations may efficiently produce greater impact.

It is important not to oversimplify the complex factors that contribute to changes in the rankings. For example, estimates of greater-than-expected impact from the food fortification program introduced in 1998^41,42 reduced the potential impact of folic acid supplements, resulting in a drop in total score from 5 in 2006 to 3 in 2016. Another example is pneumococcal vaccine. Introduction of the 13-valent pneumococcal conjugate (PCV13) vaccine in the childhood immunization series had a substantial impact on disease incidence in older adults, reducing the impact of the adult pneumococcal vaccine. Addition of the more costly PCV13 vaccine⁴³ for adults in 2014 also reduced the overall cost-effectiveness of pneumococcal vaccinations for older adults.

The accuracy of our results is limited by factors common to modeling studies. Models cannot generate estimates that are more accurate than the data for influential variables that enter the model. Further, by definition, models simplify the complex chain of causation and associations present in the real world. Consequently, different decisions about building a model structure that fits the available data while representing key dependencies could yield different results.

Other limitations of the methods previously noted^2,16,22 are worth mention. The ranking adds scores for 2 ordinal measures, clinically preventable burden and cost-effectiveness, and weights them equally to derive a total score. This method may not produce an ordering of total scores that matches the criteria important to a decision maker. We provide the separate scores for clinically preventable burden and cost-effectiveness, which can be weighted to derive an alternate order of services. These 2 measures were chosen as comprehensive metrics that indicate 2 important aspects of health services: health impact and efficiency. Other factors not reflected in these metrics—such as the impact on reducing health disparities, costs of systems to increase utilization, reimbursement, and publicly reported performance measurement—should be considered alongside these rankings in setting priorities.

We followed the reference case methods of the first Panel on Cost Effectiveness in Health and Medicine. ¹⁷ Updated recommendations from the second panel were released after all analyses were complete. The new recommendations suggest that productivity gains should be included in cost-effectiveness analysis conducted from the societal perspective and that a second reference case from the health system perspective be presented.⁴⁴ Following the first panel’s methods, we included patient time costs in receiving services. Doing so particularly affects the cost-effectiveness of services that include intensive weight management as a key part of follow-up. Relative to other services in the ranking, those preventive services likely would score higher on cost-effectiveness that is conducted from the health systems perspective. Adding productivity gains to all services in analysis from the societal perspective may not substantially change the services’ relative rankings, but we could not fully assess adding the gains for this update.

Our analysis includes only a fraction of services among which priorities for clinic time and resources must be made. It is useful to consider these rankings in a broader context. Relative differences exist in the benefits that can be achieved through more consistent use of these services; all of these services, however, have proven value in prevention and should be prioritized over services with less or no evidence. A much larger portion of primary care time is spent on diagnosis and treatment. We are not aware of any effort to begin the enormous task of discerning priorities among the whole range of medical care services. Evidence-based preventive services for higher-risk groups may be very important for those groups and are not included in our ranking. Effective community preventive services also are not included. As hospitals look for options to meet community health benefits and to help manage population health as part of accountable care organizations, they can look to resources, such as the Guide to Community Preventive Services,⁴⁵ County Health Rankings and Road Maps,⁴⁶ and the Community Health Advisor,⁴⁷ for guidance on evidence-based community preventive services.

This update does not include 4 services, listed in the Supplemental Appendix that meet our conceptual scope. An effort of this magnitude requires ongoing work to keep pace with important changes to the evidence base, underlying data, and new recommendations. We intend to develop a process of continuous updates, with incremental updates made available in a timely manner.

Recognizing these limitations, decision makers can use this ranking tool as they continue efforts to improve quality of care in a changing primary care environment. First-dollar coverage for preventive services and expanded insurance coverage through the ACA, the pursuit of the Triple Aim, and creation of PCMHs may each contribute to increased utilization of clinical preventive services. No single initiative, however, has been shown to dramatically increase utilization rates by itself. This timely update can be used to guide decisions to make the most of the opportunities presented by changes in how primary care is provided.