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. 2016 Oct 7;31(1):237–240. doi: 10.1038/leu.2016.250

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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TKI responsiveness of wild-type and mutant NDEL1-PDGFRB genes. (a) Displayed are IC₅₀ values of different TKIs against Ba/F3 cells expressing wild-type (wt) or mutant NDEL1-PDGFRβ fusion proteins. The corresponding IC₅₀ values for Ba/F3 expressing FIP1L1-PDGFRα wt and D842E are given for comparison. (b) Western blot analysis of Ba/F3 cells transduced with wild-type or mutant (R=R853H, H=H657K, HR=H657K/R853H, D=D850E and DR=D850E/R853H) NDEL1-PDGFRB genes. The phosphorylation levels of NDEL1-PDGFRβ at Y751 and Y857, and Erk are displayed. Shown are also the total expression levels of NDEL1-PDGFRβ, Erk and the control gene Gapdh upon mock treatment for 4 h with DMSO (indicated by ‘−‘) or with 100 nm nilotinib (indicated by ‘+').