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. 2017 Jan 11;69(2):275–285. doi: 10.1161/HYPERTENSIONAHA.115.07031

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© 2016 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 5. — Selective smooth muscle endothelin_B (SMET_B) deletion does not alter neointimal lesion formation. A, Wire injury–induced lesion formation in femoral arteries from control and SMET_B knockout (KO) mice. Neointimal lesion volume (B) and maximal cross-sectional area (C) were similar in control and SMET_B KO mice when measured by optical projection tomography. Similar results were obtained when maximal cross-sectional area was measured histologically (D). Volume (E) and maximal cross-sectional area (F) of lesions induced by ligation were similar in control and SMET_B KO mice (optical projection tomography [OPT]). Data are mean±SEM (n=7). EEL indicates external elastic lamina; IEL, internal elastic lamina; L, lumen; and NI, neointima.