Table 4. summarizes the DR neuronal activity following 2.5 mg/kg MPD.
Table 4 summarizes the effects of acute and chronic injection of 2.5 mg/kg MPD on DR neuronal activity. Section a. summarizes neuronal activity of DR units recorded from all rats, section b. summarizes activity recorded only from animals exhibiting behavioral sensitization, and section c. summarizes activity recorded only from tolerant animals.
indicates a significant (p < 0.05) increase in activity following MPD treatment,
indicates a significant (p < 0.05) decrease in activity following treatment, and
indicates no change.
| Dose | Population | Response direction | Acute ED1 | Baseline ED10 to ED1 | Rechallenge ED10 |
|---|---|---|---|---|---|
| 2.5 mg/kg | |||||
| a. Total N = 142 |
|
49 (34.5%) | 53 (37.3%) | 48 (33.8%) | |
|
36 (25.4%) | 45 (31.7%) | 48 (33.8%) | ||
|
57 (40.1%) | 44 (31.0%) | 46 (32.4%) | ||
| b. Behavioral Sensitization N = 62 |
|
44 (71.0%) | 49 (79.0%) | 48 (77.4%) | |
|
|
11 (17.7%) | 9 (14.5%) | 11 (17.7%) | ||
|
|
7 (11.3%) | 4 (6.5%) | 3 (4.8%) | ||
| c. Behavioral Tolerance N = 80 |
|
19 (23.8%) | 14 (17.5%) | 12 (15.0%) | |
|
|
22 (27.5%) | 36 (45.0%) | 37 (46.3%) | ||
|
|
39 (48.8%) | 30 (37.5%) | 31 (38.8%) |