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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Bioessays. 2016 Oct 21;38(12):1197–1208. doi: 10.1002/bies.201600144

Figure 5.

Figure 5

Cajal bodies influence RNA splicing kinetics. A: RNA splicing by the spliceosome is dependent on many factors that are influenced by CB function. These include snRNP availability, as the CB enhances snRNA gene transcription and snRNP assembly steps, and snRNP base modifications (guided by box H/ACA and box C/D scaRNPs). Through its physical association with the HLB, the loss of CBs has been shown to reduce histone mRNA availability. We have also observed a decrease in RNA Pol II C-terminal domain inclusion following CB disassembly. Both of these changes are suggested to decrease RNA Pol II transcription rate. B: Altogether, these results show that CB-mediated functions influence RNA splicing, RNA splice site selection and splicing fidelity.