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. 2016 Jul 12;7(31):48870–48886. doi: 10.18632/oncotarget.10549

Table 5. Multiple benefits of PIP3-binding candidate knockdowns.

Gene H2O2 survival 142 aggreg. α-synuclein aggregation Longevity effect (range) or reference
induced aging
rad-50 ↑5x ↓3x ↓10x ↓3.6x ↑15% (8 – 20%)
cand-1 ↑11x ↓5x ↓20x N.S. ↑17% (15 – 19%)
fat-2 ↑5x ↓4x ↓20x ↓40% ↑ [40]
akt-1 ↑9x N.S.  ↓3x N.S. ↑9%; [45]
tct-1 ↑7x N.S.   N.S. ↓ 2x

N.S., not significant; grey shading, not tested here. Reference citations indicate published lifespan data.