Figure 2. ME-344 displays antitumor activity in an in vivo xenograft mouse model.

Tumor derived OCI-AML2 human leukemia cells (1 × 10⁶) were injected subcutaneously into the flanks of male SCID mice. When tumors were palpable, animals were separated into four groups and were treated with ME-344 by i.p. injection (50, 75, and 100 mg/kg every other day) or vehicle control (n = 8 per group). Tumor weight (A), tumor volume (B), and body weight (C) were monitored over time. Mean ± SD; the lines are connecting the data points. *P < 0.01, **P < 0.001, and ***P < 0.0001 from a one-way ANOVA in panel (A) and a two-way ANOVA with Bonferroni posttests comparing all treatment groups in panel (B).