Figure 4.

Illustration of the differences between methods used to correct DSC-MRI concentration–time curves for recirculation and/or leakage effects. γ-variate fit to ΔR₂^*(t) (orange) (A). Proposed full model fit to ΔR₂^*(t) (red) and corrected first pass (blue) (B). Corrected first-pass curves obtained from (A) and (B), (C). Compared to the standard γ-variate (orange), the corrected first-pass curve (blue) from the proposed method is characterized by decreased peak height and bolus width, which should be more representative of the actual first pass in the absence of recirculation and leakage effects.