Skip to main content
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1994 Feb 11;22(3):354–356. doi: 10.1093/nar/22.3.354

A segment of the phage HK022 chromosome is a mosaic of other lambdoid chromosomes.

J Oberto 1, S B Sloan 1, R A Weisberg 1
PMCID: PMC523588  PMID: 8127672

Abstract

We report the sequence of a region of the PR operon of lambdoid phage HK022 and an analysis of the proteins it encodes. This region has DNA sequence elements and open reading frames that resemble those found in phages lambda, P22, and phi 80. The open reading frames encode homologs of the lambda CII transcription activator, the P22 DNA replication proteins, and a fourth protein of unknown function.

Full text

PDF
354

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Backhaus H., Petri J. B. Sequence analysis of a region from the early right operon in phage P22 including the replication genes 18 and 12. Gene. 1984 Dec;32(3):289–303. doi: 10.1016/0378-1119(84)90004-0. [DOI] [PubMed] [Google Scholar]
  2. Baker J., Limberger R., Schneider S. J., Campbell A. Recombination and modular exchange in the genesis of new lambdoid phages. New Biol. 1991 Mar;3(3):297–308. [PubMed] [Google Scholar]
  3. Cam K. M., Oberto J., Weisberg R. A. The early promoters of bacteriophage HK022: contrasts and similarities to other lambdoid phages. J Bacteriol. 1991 Jan;173(2):734–740. doi: 10.1128/jb.173.2.734-740.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387–395. doi: 10.1093/nar/12.1part1.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dhillon T. S., Dhillon E. K. Studies on bacteriophage distribution. II. Isolation and host rage based classification of phages active on three species of Enterobacteriaceae. Jpn J Microbiol. 1972 Jul;16(4):297–306. doi: 10.1111/j.1348-0421.1972.tb00662.x. [DOI] [PubMed] [Google Scholar]
  6. Dodson M., McMacken R., Echols H. Specialized nucleoprotein structures at the origin of replication of bacteriophage lambda. Protein association and disassociation reactions responsible for localized initiation of replication. J Biol Chem. 1989 Jun 25;264(18):10719–10725. [PubMed] [Google Scholar]
  7. Highton P. J., Chang Y., Myers R. J. Evidence for the exchange of segments between genomes during the evolution of lambdoid bacteriophages. Mol Microbiol. 1990 Aug;4(8):1329–1340. doi: 10.1111/j.1365-2958.1990.tb00712.x. [DOI] [PubMed] [Google Scholar]
  8. Hilliker S., Botstein D. Specificity of genetic elements controlling regulation of early functions in temperate bacteriophages. J Mol Biol. 1976 Sep 25;106(3):537–566. doi: 10.1016/0022-2836(76)90251-5. [DOI] [PubMed] [Google Scholar]
  9. Ho Y. S., Mahoney M. E., Wulff D. L., Rosenberg M. Identification of the DNA binding domain of the phage lambda cII transcriptional activator and the direct correlation of cII protein stability with its oligomeric forms. Genes Dev. 1988 Feb;2(2):184–195. doi: 10.1101/gad.2.2.184. [DOI] [PubMed] [Google Scholar]
  10. Krinke L., Mahoney M., Wulff D. L. The role of the OOP antisense RNA in coliphage lambda development. Mol Microbiol. 1991 May;5(5):1265–1272. doi: 10.1111/j.1365-2958.1991.tb01900.x. [DOI] [PubMed] [Google Scholar]
  11. Krinke L., Wulff D. L. RNase III-dependent hydrolysis of lambda cII-O gene mRNA mediated by lambda OOP antisense RNA. Genes Dev. 1990 Dec;4(12A):2223–2233. doi: 10.1101/gad.4.12a.2223. [DOI] [PubMed] [Google Scholar]
  12. LeBowitz J. H., McMacken R. The Escherichia coli dnaB replication protein is a DNA helicase. J Biol Chem. 1986 Apr 5;261(10):4738–4748. [PubMed] [Google Scholar]
  13. Oberto J., Clerget M., Ditto M., Cam K., Weisberg R. A. Antitermination of early transcription in phage HK022. Absence of a phage-encoded antitermination factor. J Mol Biol. 1993 Jan 20;229(2):368–381. doi: 10.1006/jmbi.1993.1040. [DOI] [PubMed] [Google Scholar]
  14. Oberto J., Weisberg R. A., Gottesman M. E. Structure and function of the nun gene and the immunity region of the lambdoid phage HK022. J Mol Biol. 1989 Jun 20;207(4):675–693. doi: 10.1016/0022-2836(89)90237-4. [DOI] [PubMed] [Google Scholar]
  15. Ogawa T., Ogawa H., Tomizawa J. Organization of the early region of bacteriophage phi 80. Genes and proteins. J Mol Biol. 1988 Aug 5;202(3):537–550. doi: 10.1016/0022-2836(88)90284-7. [DOI] [PubMed] [Google Scholar]
  16. Susskind M. M., Botstein D. Molecular genetics of bacteriophage P22. Microbiol Rev. 1978 Jun;42(2):385–413. doi: 10.1128/mr.42.2.385-413.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wickner S. H., Zahn K. Characterization of the DNA binding domain of bacteriophage lambda O protein. J Biol Chem. 1986 Jun 5;261(16):7537–7543. [PubMed] [Google Scholar]
  18. Wulff D. L., Mahoney M. E. Cross-specificities between cII-like proteins and pRE-like promoters of lambdoid bacteriophages. Genetics. 1987 Apr;115(4):597–604. doi: 10.1093/genetics/115.4.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yagil E., Dolev S., Oberto J., Kislev N., Ramaiah N., Weisberg R. A. Determinants of site-specific recombination in the lambdoid coliphage HK022. An evolutionary change in specificity. J Mol Biol. 1989 Jun 20;207(4):695–717. doi: 10.1016/0022-2836(89)90238-6. [DOI] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES