Table 1. Correlation between the factors and clinicopathologic characteristics in HCC (cohort 3, n=368).

Clinicopathological indexes		Sema3A			CD68			CD163
		Low	High	P	Low	High	P	Low	High	P
Age(year)	≤50	70	73	0.748	74	69	0.593	74	69	0.593
	>50	114	111		110	115		110	115
Sex	Female	31	34	0.682	33	32	0.891	33	32	0.891
	Male	153	150		151	152		151	152
HBsAg	Negative	28	25	0.656	24	29	0.458	21	32	0.102
	Positive	156	159		160	155		163	152
HCV	Negative	182	183	0.624*	183	182	0.624*	183	182	0.624*
	Positive	2	1		1	2		1	2
AFP (ng/ml)	≤20	75	64	0.237	73	66	0.452	73	66	0.452
	>20	109	120		111	118		111	118
GGT (U/L)	≤54	95	96	0.917	101	90	0.251	98	93	0.602
	>54	89	88		83	94		86	91
Liver cirrhosis	No	27	33	0.397	33	27	0.397	31	29	0.778
	Yes	157	151		151	157		153	155
Tumor size(cm)	≤5	125	99	0.005	129	95	0.000	127	97	0.001
	>5	59	85		55	89		57	87
Tumor number	Single	170	158	0.044	168	160	0.180	169	159	0.094
	Multiple	14	26		16	24		15	25
Microvascular invasion	Absence	135	118	0.111	135	118	0.111	137	116	0.018
	Present	49	65		49	65		47	68
Tumor encapsulation	Complete	111	92	0.046	107	96	0.249	106	97	0.345
	None	73	92		77	88		78	87
Tumor differentiation	I+II	138	138	1.0	144	132	0.149	146	130	0.054
	III+IV	46	46		40	52		38	54
TNM stage	I	125	103	0.018	122	106	0.086	124	104	0.032
	II+III	59	81		62	78		60	80

AFP, alpha-fetoprotein; GGT, gamma glutamyl transferase; TNM, tumor-node-metastasis.

^*Fisher's exact tests; chi-square tests for all other analyses.