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. 2016 Jul 7;7(32):51922–51933. doi: 10.18632/oncotarget.10458

Figure 4. Hippo reporter activity and downstream gene expression in HCC827 and H1975 cells.

Figure 4

A. GTIIC reporter activity of the hippo pathway significantly decreased in HCC827 cells after erlotinib treatment and increased with YAP forced overexpression (***P < 0.001). B. GTIIC reporter activity significantly decreased in YAP siRNA-transfected H1975 cells after erlotinib treatment (***P < 0.001). C. GTIIC reporter activity significantly decreased in H1975 cells after verteporfin alone and after combined treatment with verteporfin and erlotinib (*P < 0.05, **P < 0.01). D. Hippo downstream gene expression of AREG and CTGF in HCC827 cells with YAP forced overexpression significantly increased even after erlotinib treatment (*P < 0.05, **P < 0.01, ***P < 0.001). E. Hippo downstream gene expression of AREG and CTGF in YAP siRNA-transfected H1975 cells significantly decreased after erlotinib treatment (***P < 0.001). F. Hippo downstream gene expression of AREG and CTGF significantly decreased after verteporfin treatment alone and after combined treatment with erlotinib and verteporfin treatment (*P < 0.05, **P < 0.01, ***P < 0.001).