Figure 6. Effect of JMR-132 (10 μg/day) and JV-1-38 (20 μg/day) on the expression of different molecules involved in apoptosis and cell cycle in PC3 tumors.

The p53 (A) and Bax and Bcl-2 (B) protein levels were determined by Western blotting using specific antibodies. Bax/Bcl2 ratio was determined and is also shown. Immunohistochemistry using a specific antibody against Caspase 3 was performed (C). The highest number of apoptotic cells was observed in treatment control samples (black cells). Original magnification X300. Data in each bar are the means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.vs. control.