Table 5.
ADCC activity of antibodies against HCC-827 lung cancer cell line. The average ± SEM of the Emax (% compared to complete lysis) and EC20 (the interpolated antibody concentration needed to elicit 20% lysis) for different antibodies.
| Emax (%) |
EC20 (nM) |
|||
|---|---|---|---|---|
| Average | ±SEM | Average | ±SEM | |
| JNJ-61186372 - LF | 31 | 6.62 | 0.0376 | 0.0313 |
| c-Met x inert arm - LF | 24 | 5.30 | 0.1864 | N/A |
| EGFR x inert arm - LF | 30 | 6.00 | 0.0708 | 0.0591 |
| JNJ-61186372 - NF | 30 | 4.59 | 0.6446 | 0.2655 |
NF = normal levels of core fucosylation; LF = low levels of core fucosylation.