Table 3.

Measures of cardiac structure and function among ARIC participants with Stage A HF at Visit 5 stratified by the number of HF risk factors present.

	Overall (n=3,192)	1 Risk Factor (n=868)	2 Risk Factors (n=908)	3 Risk Factors (n=789)	4 Risk Factors (n=570)	Unadjusted P value	Adjusted P value
LV structure
Wall thickness (cm)	0.93 [0.88, 1.00]	0.91 [0.85, 0.97]	0.93 [0.87, 0.99]	0.95 [0.89, 1.02]	0.96 [0.90, 1.04]	<0.0001	<0.0001
Mass/height2.7 (g/m2.7)	33.3 [29.0, 37.2]	31.5 [27.4, 35.9]	32.9 [28.9, 36.8]	33.8 [29.7, 37.5]	35.3 [31.4, 38.8]	<0.0001	<0.0001
EDV/BSA (ml/m2)	39.6 [34.5, 45.4]	40.9 [36.0, 46.6]	39.3 [34.7, 44.9]	39.0 [33.9, 44.7]	38.4 [33.3, 44.4]	<0.0001	<0.0001
Systolic Function
LVEF (%)	66.7 [63.7, 69.9]	66.6 [63.7, 69.9]	66.9 [63.7, 69.9]	66.6 [64.0, 69.9]	66.7 [63.4, 70.2]	0.53	0.18
LS (%)	−18.5 [−19.9, −17.0]	−18.7 [−20.1, −17.2]	−18.6 [−19.9, −17.1]	−18.5 [−19.8, −16.9]	−18.1 [−19.7, −16.5]	0.0001	<0.0001
Diastolic Function
TDI e′ (cm/s)	5.7 [4.8, 6.6]	5.8 [5.0, 6.9]	5.7 [4.8, 6.6]	5.6 [4.8, 6.4]	5.6 [4.7, 6.5]	<0.0001	<0.0001
E/e′ ratio	11.3 [9.3, 13.7]	10.9 [9.0, 13.1]	11.3 [9.3, 13.6]	11.5 [9.5, 14.0]	11.9 [9.6, 14.8]	<0.0001	<0.0001
LAVi (ml/m2)	22.9 [18.9, 27.3]	23.1 [19.3, 27.6]	22.6 [18.8, 27.1]	22.9 [19.1, 27.1]	22.9 [18.9, 27.5]	0.49	0.27
Soluble biomarkers
NT-proBNP (ng/L)	108 [58, 200]	110 [63, 195]	111 [60, 209]	101 [54, 182]	109 [53, 221]	0.087	0.63
Hs-TnT (ng/L)	10 [7, 15]	9 [7, 13]	9 [7, 14]	10 [7, 15]	12 [8, 18]	<0.0001	<0.0001

Values presented are median [interquartile range]. P values are for trend across risk factor categories. Adjusted P value is adjusted for age, sex, race, and Field Center. EDV – end-diastolic volume, BSA – body surface area, LVEF – left ventricular ejection fraction, LS – LV longitudinal strain, LAVi – left atrial volume index, hs-TnT – high sensitivity troponin-T