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. 1991 Sep 15;88(18):8062–8066. doi: 10.1073/pnas.88.18.8062

Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse.

S J Bultman 1, L B Russell 1, G A Gutierrez-Espeleta 1, R P Woychik 1
PMCID: PMC52446  PMID: 1896452

Abstract

Molecular characterization of a radiation-induced agouti (a)-locus mutation has resulted in the isolation of a segment of DNA that maps at or near the a locus on chromosome 2 in the mouse. This region of DNA is deleted in several radiation- or chemical-induced homozygous-lethal a-locus mutations and is associated with specific DNA structural alterations in two viable a-locus mutations. We propose that DNA probes from this region of chromosome 2 will be useful for ultimately characterizing the individual gene or genes associated with a-locus function.

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Selected References

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