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. 2017 Jan 17;19(2):135–144. doi: 10.1016/j.neo.2016.12.003

Figure 7.

Figure 7

In vivo mouse model to prove the effects of C1QBP/YBX1/AR signals on RCC cell invasion. Luc-OSRC2 (control), luc-OSRC2 + pLK0.1-YBX1 (pLKO.1YBX1) and luc-OSRC2 + pLK0.1-YBX1 + pWPI-AR (pLK0.1-YBX1 + pWPI-AR) cells were implanted into nude mice. The reporter gene signals were detected by IVIS imaging system. (A) The tumor growth (upper panels) and metastatic tumors in lung and enterocoelia (lower panels, red arrows) were detected by IVIS system. (B) Quantified data for bioluminescence in metastatic sites for mice of 3 groups. (C) Quantification of the tumor metastasis. (D) Mouse tumor samples were collected for IHC staining for AR, YBX1, and MMP9 (**P < 0.01).