Table 2.
Metabolic parameters in normal wild-type mice
| Parameter | YFP | Ad5E4ORF1 low | Ad5E4ORF1 high | Ad36E4ORF1 low | Ad36E4ORF1 high |
|---|---|---|---|---|---|
| Serum glucose (mg/dL) | 226.5 ± 18.8 | 193.1 ± 12.3 | 210.1 ± 8.3 | 201.4 ± 8.6 | 146.6 ± 20.5** |
| Serum insulin (ng/mL) | 0.71 ± 0.35 | 0.61 ± 0.15 | 0.53 ± 0.14 | 0.65 ± 0.17 | 0.29 ± 0.08 |
| Serum cholesterol (mg/dL) | 76.3 ± 6.7 | 90.5 ± 11.0 | 80.3 ± 7.8 | 98.6 ± 9.6 | 73.7 ± 11.0 |
| Serum triglycerides (mg/dL) | 75.6 ± 11.6 | 54.6 ± 5.6 | 74.6 ± 8.9 | 61.0 ± 4.2 | 137.9 ± 14.7** |
| Serum NEFA (mEQ/L) | 0.41 ± 0.04 | 0.50 ± 0.04 | 0.48 ± 0.05 | 0.54 ± 0.12 | 0.80 ± 0.08 |
| Serum leptin (ng/mL) | 1.20 ± 0.29 | 1.73 ± 0.25 | 1.39 ± 0.35 | 1.95 ± 0.34 | 1.22 ± 0.38 |
| Liver cholesterol (mg/g) | 0.91 ± 0.07 | 0.96 ± 0.10 | 1.04 ± 0.15 | 0.74 ± 0.07 | 1.16 ± 0.25 |
| Liver triglyceride (mg/g) | 1.01 ± 0.11 | 1.30 ± 0.24 | 1.51 ± 0.21 | 1.74 ± 0.26 | 4.68 ± 0.82** |
| Liver NEFA (mEQ/g) | 0.017 ± 0.002 | 0.014 ± 0.001 | 0.035 ± 0.002* | 0.012 ± 0.001 | 0.041 ± 0.003** |
| Liver glycogen (mg/g) | 83.8 ± 3.2 | 70.4 ± 5.4 | 75.7 ± 5.1 | 74.5 ± 3.1 | 51.1 ± 3.6** |
Data are mean ± SEM. Low, 2 × 109 vg/mouse; high, 2 × 1010 vg/mouse. n = 5/group. NEFA, nonesterified fatty acid.
*P < 0.05,
**P < 0.01 vs. YFP.