Table 2.
Patient characteristics (n = 116)
| Variable | n (%)pvalue* | |
|---|---|---|
| Age, mean (range) | 56.5 (39-77)ns | |
| Sex | Male | 94 (81.0)e |
| Female | 22 (19.0)− | |
| Primary Site | Base of Tongue | 71 (61.2)ns |
| Tonsil | 45 (38.8)− | |
| Tumor stage | T1 | 28 (24.1)c,e,f,p |
| T2 | 47 (40.5)c,e,f,p | |
| T3 | 30 (25.9)ns | |
| T4 | 11 (9.5)− | |
| Nodal stage | N0/1/2a | 11 (9.5)ns |
| N2b | 49 (42.2)ns | |
| N2c | 43 (37.1)c,e,p | |
| N3 | 13 (11.2)− | |
| HPV/p16 status | p16pos &/OR HPVpos | 77 (66.4)na |
| p16neg & HPVneg | 1 (0.8)na | |
| P16unknown & HPVneg | 9 (7.8)na | |
| P16unknown & HPVunknown | 29 (25.0)na | |
| Smoking status | Current | 25 (21.6)c,e,f,p |
| Former | 35 (30.2)ns | |
| Never | 56 (48.3)− | |
| Pack years, mean (range) | All patients | 14.8 (0-132)c,f |
| p16unknown & HPVunknown | 8.1 (0-45)− | |
| Treatment | Induction + Concurrent/IMRT | 46 (39.7)p |
| Concurrent/IMRT | 19 (16.4)ns | |
| Induction + IMRT | 51 (44.0)− | |
| IMRT Dosing | 66Gy | 36 (31.0)ns |
| ≥70Gy | 80 (69.0)− | |
| Post-treatment neck dissection | No | 93 (80.2)ns |
| Yes | 23 (19.8)− | |
Abbreviations: T, tumor; N, node; HPV, human papillomavirus; IMRT, intensity modulated radiotherapy; Gy, gray.
Superscripts:
*
Univariate longitudinal mixed effects mode with linear spline for MDADI composite and subscale scores, p-value <0.05 is significant; ns, not significant
c
composite p-value<0.05
e
emotional subscale p-value<0.05
f
functional subscale p-value<0.05
p
physical subscale p-value<0.05.