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. 1991 Oct 1;88(19):8582–8586. doi: 10.1073/pnas.88.19.8582

Characterization of a neu/c-erbB-2 protein-specific activating factor.

K Dobashi 1, J G Davis 1, Y Mikami 1, J K Freeman 1, J Hamuro 1, M I Greene 1
PMCID: PMC52553  PMID: 1717981

Abstract

The neu oncogene encodes a tyrosine kinase with growth factor receptor-like properties. A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu protein (p185neu), induce dimerization and internalization, and increase the growth of cells bearing the neu protein. The effects of NAF were mediated by an interaction with the p185neu extracellular domain. NAF had no effect on the epidermal growth factor receptor kinase activity and no effect on cells that express that receptor. Further analysis of NAF and of other recently described neu protein-activating activities should help clarify the role of the neu protein in cell growth and transformation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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