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. 2016 Jul 13;66(1):59–69. doi: 10.1136/gutjnl-2015-310874

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Acute administration of thioguanine (TG) improved spontaneous Winnie murine colitis. C57Bl/6 (wild-type (WT), open symbols) and Winnie (grey symbols) were daily gavaged TG 0, 0.5, 1 or 2.5 mg/kg for up to 14 days. (A) Blinded scoring of histological colitis for proximal colon (PC) and distal colon (DC); (B) representative H&E for PC and DC of WT and Winnie treated with daily TG 0 or 2.5 mg/kg and (C) mRNA fold change normalised to β-actin gene and to WT control of Tnf-α, Ifn-γ, interleukin (Il)-1b, Il-17 and Muc2. Box-and-whisker plots of median, quartiles and range, N=4–6. Symbols: *versus WT TG 0 mg/kg; ^#versus Winnie TG 0 mg/kg. Statistical analysis: Mann-Whitney non-parametric test. Scale bar=100 μm.