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. 1978 Dec;28(3):710–716. doi: 10.1128/jvi.28.3.710-716.1978

Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.

M D Lubeck, J L Schulman, P Palese
PMCID: PMC525794  PMID: 731792

Abstract

Influenza A virus recombinants derived from "resistant" and "sensitive" parental viruses were examined for susceptibility to inhibition by amantadine. Correlation of gene constellation and amantadine susceptibility revealed that the gene coding for M protein influences sensitivity or resistance to amantadine. All recombinants which derived an M protein from an amantadine-resistant parent were found to be resistant to amantadine. All amantadine-sensitive recombinants derived an M gene from the amantadine-sensitive parent. However, a few amantadine-resistant recombinants which derived an M gene from the sensitive parent were also isolated, suggesting that the expression of amantadine sensitivity in these recombinants may be influenced by other genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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