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. 1978 Dec;28(3):717–724. doi: 10.1128/jvi.28.3.717-724.1978

Replication of RNA bacteriophages in the presence of rifamycin.

V Bauman, P Pumpen, A Dishler, E J Gren
PMCID: PMC525795  PMID: 366177

Abstract

Replication of RNA bacteriophages in the presence of rifamycin was studied in different Escherichia coli strains that vary in RNase content but are not isogenic: AB259 RNase+, Q13 RNase I- PNPase-, AB105 RNase I- RNase III-. It was found that rifamycin did not affect characteristics of phage replication such as the general pattern of viral RNA synthesis and intracellular development of the phage. These characteristics are strain specific and independent of the cell growth rate, which defines only phage release. The inhibition of cell division by rifamycin interfered with the release of the phage and thus produced an apparent effect of rifamycin on phage replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bandle E., Weissmann C. Rifampicin and the replication of the RNA-containing bacteriophage Q-beta. Biochim Biophys Acta. 1970 Feb 18;199(2):551–553. doi: 10.1016/0005-2787(70)90105-x. [DOI] [PubMed] [Google Scholar]
  2. Bauman V. R., Markushevich V. N., Kish A. Z., Gren E. Ia. Sravnitel'naia fiziologiia replikatsii RNK-soderzhashchikh bakteriofagov MS2 i Q beta. Mikrobiologiia. 1976 Jul-Aug;45(4):685–689. [PubMed] [Google Scholar]
  3. Billeter M. A., Weissmann C., Warner R. C. Replication of viral ribonucleic acid. IX. Properties of double-stranded RNA from Escherichia coli infected with bacteriophage MS2. J Mol Biol. 1966 May;17(1):145–173. doi: 10.1016/s0022-2836(66)80101-8. [DOI] [PubMed] [Google Scholar]
  4. Cramer J. H., Sinsheimer R. L. Use of miracil D to suppress bacterial ribonucleic acid and protein synthesis during bacteriophage MS2 infection. J Virol. 1972 Feb;9(2):189–199. doi: 10.1128/jvi.9.2.189-199.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DAVIS J. E., SINSHEIMER R. L. The replication of bacteriophage MS2. 1. Transfer of parental nucleic acid to progeny phage. J Mol Biol. 1963 Mar;6:203–207. doi: 10.1016/s0022-2836(63)80069-8. [DOI] [PubMed] [Google Scholar]
  6. Engelberg H., Brudo I., Israeli-Reches M. Discriminative effect of rifampin of RNA replication of various RNA bacteriophages. J Virol. 1975 Aug;16(2):340–347. doi: 10.1128/jvi.16.2.340-347.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Engelberg H. Inhibition of RNA bacteriophage replication by rifampicin. J Mol Biol. 1972 Jul 28;68(3):541–546. doi: 10.1016/0022-2836(72)90107-6. [DOI] [PubMed] [Google Scholar]
  8. Engelberg H., Soudry E. Ribonucleic acid bacteriophage release: requirement for host-controlled protein synthesis. J Virol. 1971 Sep;8(3):257–264. doi: 10.1128/jvi.8.3.257-264.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FENWICK M. L., ERIKSON R. L., FRANKLIN R. M. REPLICATION OF THE RNA OF BACTERIOPHAGE R17. Science. 1964 Oct 23;146(3643):527–530. doi: 10.1126/science.146.3643.527. [DOI] [PubMed] [Google Scholar]
  10. Friedrich R., Feix G. RNA-RNA hybridization in aqueous solutions containing formamide. Anal Biochem. 1972 Dec;50(2):467–476. doi: 10.1016/0003-2697(72)90056-5. [DOI] [PubMed] [Google Scholar]
  11. Fromageot H. P., Zinder N. D. Growth of bacteriophage f2 in E. coli treated with rifampicin. Proc Natl Acad Sci U S A. 1968 Sep;61(1):184–191. doi: 10.1073/pnas.61.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hartmann G., Honikel K. O., Knüsel F., Nüesch J. The specific inhibition of the DNA-directed RNA synthesis by rifamycin. Biochim Biophys Acta. 1967;145(3):843–844. doi: 10.1016/0005-2787(67)90147-5. [DOI] [PubMed] [Google Scholar]
  13. Haywood A. M., Harris J. M. Actinomycin inhibition of MS2 replication. J Mol Biol. 1966 Jul;18(3):448–463. doi: 10.1016/s0022-2836(66)80036-0. [DOI] [PubMed] [Google Scholar]
  14. Haywood A. M., Sinsheimer R. L. The replication of bacteriophage MS2. V. Proteins specifically associated with infection. J Mol Biol. 1965 Dec;14(2):305–326. doi: 10.1016/s0022-2836(65)80184-x. [DOI] [PubMed] [Google Scholar]
  15. Kindler P., Keil T. U., Hofschneider P. H. Isolation and characterization of a ribonuclease 3 deficient mutant of Escherichia coli. Mol Gen Genet. 1973 Oct 16;126(1):53–59. doi: 10.1007/BF00333481. [DOI] [PubMed] [Google Scholar]
  16. LOEB T., ZINDER N. D. A bacteriophage containing RNA. Proc Natl Acad Sci U S A. 1961 Mar 15;47:282–289. doi: 10.1073/pnas.47.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lunt M. R., Sinsheimer R. L. Inhibition of ribonucleic acid bacteriophage growth by actinomycin D. J Mol Biol. 1966 Jul;18(3):541–546. doi: 10.1016/s0022-2836(66)80042-6. [DOI] [PubMed] [Google Scholar]
  18. Marino P., Baldi M. I., Tocchini-Valentini G. P. Effect of rifampicin on DNA-dependent RNA polymerase and on RNA phage growth. Cold Spring Harb Symp Quant Biol. 1968;33:125–127. doi: 10.1101/sqb.1968.033.01.016. [DOI] [PubMed] [Google Scholar]
  19. Meier D., Hofschneider P. H. Effect of rifampicin on the growth of RNA bacteriophage M12. FEBS Lett. 1972 Sep 1;25(1):179–183. doi: 10.1016/0014-5793(72)80480-0. [DOI] [PubMed] [Google Scholar]
  20. Passent J., Kaesberg P. Effect of rifampin on the development of ribonucleic acid bacteriophage Q . J Virol. 1971 Sep;8(3):286–292. doi: 10.1128/jvi.8.3.286-292.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Propst-Ricciuti B. The effect of host-cell starvation on virus-induced lysis by MS2 bacteriophage. J Gen Virol. 1976 Jun;31(3):323–330. doi: 10.1099/0022-1317-31-3-323. [DOI] [PubMed] [Google Scholar]
  22. Pumpen P. P., Gren E. Ia. Obratimast' konkurentsii sinteza ribosomal'noi RNK i fagovoi RNK v zarazhennykh RNK-soderzhashchimi bakteriofagami kletkakh Escherichia coli. Biokhimiia. 1977 Oct;42(10):1835–1840. [PubMed] [Google Scholar]
  23. Pumpen P. P., Gren E. Ia. Rol' belkovogo sinteza v reguliatsii replikatsii RNK-soderzhashchikh bakteriofagov. Dokl Akad Nauk SSSR. 1975 Sep-Oct;224(1):246–248. [PubMed] [Google Scholar]
  24. Pumpen P., Bauman V., Dishler A., Gren E. J. Control of replication in RNA bacteriophages. J Virol. 1978 Dec;28(3):725–735. doi: 10.1128/jvi.28.3.725-735.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rohrmann G. F., Krueger R. G. Physical, biochemical, and immunological properties of coliphage MS-2 particles. J Virol. 1970 Sep;6(3):269–279. doi: 10.1128/jvi.6.3.269-279.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Rothwell J. D., Yamazaki H. Limited production of R17 ribonucleic acid phage in the presence of rifampin. Biochemistry. 1972 Aug 29;11(18):3333–3338. doi: 10.1021/bi00768a005. [DOI] [PubMed] [Google Scholar]
  27. SINSHEIMER R. L., STARMAN B., NAGLER C., GUTHRIE S. The process of infection with bacteriophage phi-XI74. I. Evidence for a "replicative form". J Mol Biol. 1962 Mar;4:142–160. doi: 10.1016/s0022-2836(62)80047-3. [DOI] [PubMed] [Google Scholar]

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