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. 1978 Sep;27(3):713–724. doi: 10.1128/jvi.27.3.713-724.1978

Identification of a herpesvirus isolated from cytomegalovirus-transformed human cells.

L Geder, R W Hyman, M Figueroa, J E Oakes, J P Iltis, M S Dawson, F Rapp
PMCID: PMC525859  PMID: 212591

Abstract

Human cells transformed by cytomegalovirus and transplanted to athymic nude mice yielded a cytopathic virus, Hershey Medical Center virus, following prolonged in vitro passage of the tumor cells. The virus is a double-enveloped herpesvirus, is sensitive to ether, and is inhibited by iododeoxyuridine. No significant antigenic relationship to herpes simplex virus was detected using herpes simplex virus-immune sera in neutralization and immunofluorescence tests, but indirect immunofluorescence tests revealed cytomegalovirus-related antigenicity. Further immunological tests revealed that Hershey Medical Center virus is antigenically indistinguishable from infectious bovine rhinotracheitis virus. Thus, it appears that Hershey Medical Center virus is infectious bovine rhinotracheitis virus, which presumably appeared in the cell culture as a contaminant from fetal calf serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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