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. 1991 Oct 15;88(20):8900–8904. doi: 10.1073/pnas.88.20.8900

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

M A Kennedy 1, R Gonzalez-Sarmiento 1, U R Kees 1, F Lampert 1, N Dear 1, T Boehm 1, T H Rabbitts 1
PMCID: PMC52618  PMID: 1681546

Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

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Selected References

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