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. 2017 Jan 24;8(1):e02237-16. doi: 10.1128/mBio.02237-16

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Copyright © 2017 De Oliveira et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — M1 protein binds blood group antigen-related structures with various affinities. (a) Structural comparison of glycans used in SPR binding experiments. Index numbers correspond to glycan index numbers used in Table S1. M1 binding to (b) lacto-N-tetraose (LNT; Galβ1-3GlcNAcβ1-3Galβ1-4Glc), negative binding control α-Neu5Ac, (c) H antigen type I (Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1-4Glc), and (d) blood group A trisaccharide [A-tri; GalNAcα1-3(Fucα1-2)Gal] and blood group B trisaccharide [B-tri; Galα1-3(Fucα1-2)Gal] was determined via SPR and modeled using steady-state affinity fitting of the single-cycle kinetic sensorgrams. Affinity constants for the binding interactions are provided in the figure panels.