Table 1.

Meaning of parameters in the dynamical models presented in Figure 1. The upper part gives prior means and standard deviations for normal a priori distributions used for estimation of mechanistic parameters in Model 7 for the ‘Target cell model’. The lower part gives parameter values used for data simulation from the Adams et al. (2005) model.

			Normal priors used for analysis* on the log value of the parameter
Name	Description		mean	sd.
λ	Natural production rate	$\frac{\text{cells}}{\mu L.\text{day}}$	2.55	1.90
μ T*	Natural death rate of T* cells	$\frac{1}{\text{day}}$	−0.05	0.68
μ Q	Natural death rate of Q cells	$\frac{1}{\text{day}}$	−9.00	1.00
α	Transition rates between Q and T cells	$\frac{1}{\text{day}}$	−4.00	2.00
ρ	Transition rates between T and Q cells	$\frac{1}{\text{day}}$	−4.34	1.38
μ T	Virions natural death rate	$\frac{1}{\text{day}}$	−2.59	0.34
γ	Infectivity parameter	$\frac{\mu L}{\text{day}}$	−5.76	4.02
π	Rate of production of virions by infected cells	$\frac{1}{\text{day}}$	4.04	2.66
μ V	Natural death rate of T* cells	$\frac{1}{\text{day}}$	2.83	0.68

			Parameter Value used for simulations for each population (X)†
Name	Description	Units	Type 1	Type 2	Effectors	Virus
λ X	Natural production rate	$\frac{\text{cells}}{\mathit{mL}.\text{day}}$	5000	31.98	1.0	-
(1-ϵX)	Treatment efficacy	no unit	50%	83%	-	-
dX	Natural death rate	$\frac{1}{\text{day}}$	0.01	0.01	0.25	-
δ X	Infection-induced death rate	$\frac{1}{\text{day}}$	0.7	0.7	0.1	-
ρ X	Number of virions infecting a cell	$\frac{\text{virions}}{\text{cells}}$	1	1	-	-
mX	Immune-induced clearance rate	$\frac{\mathit{mL}}{\text{cells}.\text{day}}$	1 × 10−5	1 × 10−5	-	-
kX	Infection rate	$\frac{\mathit{mL}}{\text{virions}.\text{day}}$	8 × 10−7	1 × 10−4	-	-
c	Virions natural death rate	$\frac{1}{\text{day}}$	-	-	-	13
NT	Virions production per infected cells	$\frac{\text{virions}}{\text{cells}}$	-	-	-	100
Kb	Saturation constant cells birth	$\frac{\text{cells}}{\mathit{mL}}$	-	-	100	-
Kd	Saturation constant cells death	$\frac{\text{cells}}{\mathit{mL}}$	-	-	500	-
bE	Infection-induced birth rate for E cells	$\frac{1}{\text{day}}$	-	-	0.3	-

^*Reference and explanation for these choices can be found in Prague et al. (2012).

^†For each simulated patient, every parameter got a random effect leading to 50% coefficient of variation