– Which drugs are useful? |
– Which strategy of delivery is appropriate: systemic, locally intratympanic, locally intracochlear, or directly via the implant? |
– Which time of application is reasonable in the context of extracochlear and systemic therapy: before, during, or after CI implantation? |
– Which formulation and which carrier should be used? |
– Which delivery system should be applied? |
– Which dose should be applied? |
– What are the pharmacokinetic characteristics? |
– What is the additional benefit of additional drug application? |
– What is the risk–benefit ratio? |