Table 1.
Overview on the imprecision and linear range of LC-MS-based IGF-I assay reported in literature
| Year | MSIA | Quantitative approach | Calibration curve | Max. imprecision of quantitation | Linear range (ng/ml) | Reference |
|---|---|---|---|---|---|---|
| 2001 | N | Top-down | Pure standard | Not available | 30-500 | (23) |
| 2001 | N | Top-down | Pure standard and standard addition in plasma | Not available | 310-1480 | (22) |
| 2004 | Y | Top-down | Pure standard | Not available | 7.8-1000 | (27) |
| 2007 | N | Bottom-up | Standard addition in serum or plasma | 30.00% | 2000-8000 | (24) |
| 2008 | Y | Top-down | Standard addition in serum or plasma | 12.00% | 50-1000 | (28) |
| 2008 | Y | Top-down | Known plasma samples | 8.05% | 318-898 | (29) |
| 2009 | N | Bottom-up | Standard addition in serum or plasma | 17.00% | 15.6-2000 | (25) |
| 2011 | N | Top-down | Standard addition in artificial matrix | 5.20% | 15.6-2000 | (30) |
| 2012 | N | Top-down | Standard addition in artificial matrix | 6.50% | 15-2000 | (15) |
| 2012 | Y | Top-down | Standard addition in urine matrix | 18.50% | Not available | (43) |
| 2013 | N | Bottom-up | Standard addition in serum or plasma | Not available | 254-4230 | (44) |
| 2013 | Y | Bottom-up | Pure standard | 7.36% | 1-1500 | (45) |
| 2013 | N | Top-down | Standard addition in human or chicken whole blood | 11.00% | 50-600 | (46) |
| 2014 | N | Bottom-up | Standard addition in rat serum | 5.60%* | 100-1000 | (42) |
| 2014 | N | Top-down | Standard addition in rat serum | 4.80% | 50-1000 | (47) |
| 2014 | Y | Top-down | Standard addition in artificial matrix | 9.75% | 5-1500 | (32) |
| 2015 | N | Bottom-up | Standard addition in serum or plasma | < 15% | 50-3200 | (26) |
| 2015 | N | Top-down | Not available | Not available | Not available | (31) |
MSIA: mass spectrometric immunoassay
*Average value calculated from 4 laboratories.