Table 3.
Association of abnormal measures of LV diastolic function with death or incident HF hospitalization, using ARIC-base reference values versus guideline-based cutpoints.
| ARIC-based | Guideline-based | |||||||
|---|---|---|---|---|---|---|---|---|
| Cutoff | Percent Abnormal |
HR (95% CI) | P value |
Cutoff | Percent Abnormal |
HR (95% CI) | P value |
|
| TDI e’septal (cm/sec) | <4.5 (F), <4.6 (M) | 21% | 1.66 (1.20–2.29) | 0.002 | <7 | 82% | 1.11 (0.74–1.68) | 0.61 |
| TDI e’lateral (cm/sec) | <5.1 (F, <5.4 (M) | 18% | 1.64 (1.18–2.28) | 0.004 | <10 | 91% | 0.80 (0.49–1.30) | 0.37 |
| E/e’septal ratio | >15.1 (F), >13.3 (M) | 25% | 2.09 (1.55–2.83) | <0.001 | >15 | 20% | 1.94 (1.41–2.67) | <0.001 |
| E/e’lateral ratio | >13.3 (F), >11.5 (M) | 20% | 2.09 (1.53–2.85) | <0.001 | >13 | 17% | 2.17 (1.57–3.00) | <0.001 |
| LAD (cm) | >3.7 (F), >4.0 (M) | 28% | 2.37 (1.76–3.19) | <0.001 | >4.0 | 16% | 2.50 (1.80–3.49) | <0.001 |
| LAVi (ml/m2) | > 30 (F), >31 (M) | 23% | 2.31 (1.70–3.13) | <0.001 | >34 | 14% | 2.89 (2.09–3.98) | <0.001 |
All Cox proportional hazard models adjusted for age, sex, and race.