YAP overexpression |
ApoE-rtTA; TRE Yap |
hepatomegaly, HCC |
20 |
|
LAP1-tTA;TetO-Yap(S127A) |
hepatomegaly, HCC |
19 |
|
Ck19-CreERT2;TetO-Yap(S127A) |
ductal hyperplasia |
30 |
|
AAV-Cre; TetO-Yap(S127A) |
dedifferentiation, hepatomegaly, HCC |
30 |
|
Yap(S112A)/Yap(S112A) |
no change at baseline, hypertrophy after injury |
24 |
YAP knockout |
AAV-TBG-Cre; Yap fl/fl |
hepatocyte sensitivity to stress |
30 |
|
Alb-Cre; Yap fl/fl |
biliary and hepatocyte hypoplasia |
42 |
MOB1A and MOB1B |
Mob1a Δ/Δ 1b tr/+ |
HCC development |
26, 27 |
Knockout of MST1 and MST2 |
Ad-Cre; Mst1−/−; Mst fl/fl |
HCC development |
21 |
|
Alb-Cre; Mst1−/− Mst fl/- |
|
22 |
|
Alb-Cre; Mst1−/− Mst fl/fl |
|
23 |
Knockout of NF2 |
Alb-Cre; Nf2 fl/fl |
biliary ductular reaction, HCC |
42 |
|
Ad-Cre; Nf2 fl/fl |
|
43 |
Knockout of SAV |
Alb-Cre; Sav1 fl/fl |
Hepatic progenitor expansion, HCC, CC |
25 |
Knockout of NF2 and SAV |
Alb-Cre; NF2 fl/fl Sav1 fl/fl |
Biliary cell hyperplasia |
44 |
Knockout of LATS1 and LATS2 |
Ad-Cre; Lats1−/−; Lats 2 fl/fl |
Hepatomegaly, biliary cell expansion |
24 |
Knockout of α-catenin |
ΛNΠ α-catenin siRNA |
Hepatomegaly, disorganized sinusoids, cholestasis, |
51 |