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Comparison of the hydrophobicity plots of amino acid variants of three S. pneumoniae protein vaccine candidates [A] SP0148, [B] SP1912 and [C] SP2108. The vertical axis represents hydrophilicity values; the y axis indicates amino acid number. The region of maximal hydrophilicity in each plot is likely to be the antigenic site. The black data line represents the antigenicity values for each of the three proteins from the TIGR4 reference.
