Figure 8. Treatment with MOG peptide-pulsed Mino-DCs ameliorates EAE.

A. Mice were injected i.v. with MOG peptide-pulsed Mino-DCs on days -7 and -3, and EAE was induced on day 0. The clinical score was checked every third day. Three independent experiments were performed, and a representative result is shown; the data are expressed as the mean ± SD for at least four animals. B. CD4 T cells were isolated from the spleens of PBS-treated EAE mice (EAE CD4 T cell) or normal mice (Normal CD4 T cell), and then restimulated with MOG peptide-pulsed Ctrl-DCs or Mino-DCs.