Table 2. Patients’ characteristics.
Clinical parameter | IK6-positive | IK6-negative | P value | ||
---|---|---|---|---|---|
(n=20) | (n=22) | ||||
N | % | N | % | ||
Gender | |||||
Male | 11 | 55 | 13 | 59.1 | 0.789 |
Female | 9 | 45 | 9 | 40.9 | |
Age(years) | |||||
18-39 | 10 | 50 | 12 | 54.5 | 0.918 |
40-64 | 6 | 30 | 7 | 31.8 | |
≥65 | 4 | 20 | 3 | 13.6 | |
White blood cells count (cells×109/L) | |||||
<30 | 4 | 20 | 15 | 68.2 | 0.005 |
30-100 | 6 | 30 | 4 | 18.2 | |
>100 | 10 | 50 | 3 | 13.7 | |
aEarly clinical response | |||||
Yes | 6 | 30 | 15 | 68.2 | 0.013 |
No | 14 | 70 | 7 | 31.8 | |
BCR-ABL1 | |||||
p190 | 11 | 55 | 14 | 63.6 | 0.569 |
p210 | 9 | 45 | 8 | 36.4 | |
Imatinib exposure | |||||
Yes | 13 | 65 | 16 | 72.7 | |
No | 7 | 35 | 6 | 27.3 | |
bHSCT | |||||
Yes | 4 | 20 | 7 | 31.8 | |
No | 16 | 80 | 15 | 68.2 | |
cMRD risk group | |||||
Standard risk | 4 | 20 | 12 | 54.5 | 0.036 |
Intermediate risk | 9 | 45 | 8 | 36.4 | |
High risk | 7 | 35 | 2 | 9.1 |
Early clinical response was defined as≤5% leukemic blast cells in the bone marrow at day 21 (depending on national induction protocols).
HSCT, hematopoietic stem cell transplantation.
Minimal residual disease (MRD), standard risk: negative after induction therapy on treatment day 33 and consolidation therapy on treatment day 78, high risk: still positive at an MRD level of ≥103 after consolidation therapy on treatment day 78, intermediate risk: all others.