Table 5. Effect of background strain on the magnitude of CAG expansions.
| Strain | Intercept | P-Value |
|---|---|---|
| B6J | 1.09 | NA |
| B6N | 0.27 | 0.001 |
| 129 | −0.17 | <0.001 |
| CD1 | −0.09 | <0.0001 |
| DBA | 0.33 | 0.054 |
| FVB | 0.31 | 0.005 |
CAG changes in offspring were modeled, as a function of paternal CAG repeat length and strain background, in a mixed effect model context with random intercept. Paternal CAG repeat significantly explained variance in size of CAG expansions, with an estimated effect size of 0.017 increase in expansion magnitude per paternal CAG repeat unit increment (P = 0.0182). P-values represent significance when compared to the reference strain B6J.