COMMENTARY. For the article “An emerging consensus for telomerase RNA structure,” by Jiunn-Liang Chen and Carol W. Greider, which appeared in issue 41, October 12, 2004, of Proc. Natl. Acad. Sci. USA (101, 14683-14684; first published October 4, 2004; 10.1073/pnas.0406204101), the authors note that the uracil residue at position 769 was omitted from Fig. 2 B and C. The corrected figure and its legend appear below.
Fig. 2.
Two possible structures in yeast telomerase RNA core. (A) Sequence alignment of regions of the proposed pseudoknot and helix V. The sequence alignment and nucleotide numbering of telomerase RNAs from eight Saccharomyces species are adapted from Dandjinou et al. (6). Invariant residues are highlighted in yellow. Residues that show covariation are indicated by green dots. (B) A possible secondary structure of Est2 binding domain, proposed by Lin et al. (7), consists of the stem-1, supported by one nucleotide covariation at the base pair 714G:770C. (C) An alternative structure, proposed by Dandjinou et al. (6), consists of the helix V, supported by one nucleotide covariation at the base pair 714G:731C. Potential base pairings between the loops of helix V and helix VI, as proposed by Dandjinou et al. (6), are indicated by black dots. Both structures consist of a helix called stem-2 (7) or helix VI (6).