Table 2.

Multivariate Survival Analysis to Cirrhosis Among HIV/HCV co-infected veterans N 5,985

	ALT ≤ 40 IU/L	P-value	ALT >40 IU/L	P-value
	N = 273		N = 1992
	HR (CI)		HR (CI)
Race
White/other/unknown	reference
Black	0.64 (0.48–0.84)	0.001	0.67 (0.61–0.74)	<.0001
Age at index, years
<40	reference
40–50	1.84 (1.16–2.92)	0.009	1.14 (1.00–1.30)	0.047
>50	2.54 (1.54–4.18)	0.0002	1.28 (1.09–1.50)	0.002
Deyo Comorbidity Score (without HIV)
0	reference
1	1.2 (0.84–1.75)	0.29	1.1 (0.96–1.27)	0.17
≥2	3.23 (2.31–4.50)	<.0001	1.5 (1.28–1.93)	<.0001
Era of HIV Diagnosis
Pre-cART	reference
Early cART	0.83 (0.64–1.10)	0.19	0.93 (0.85–1.03)	0.19
Late cART	0.87 (0.61–1.26)	0.47	0.96 (0.84–1.1)	0.59
CD4 Count, cells/μL
<200	2.4 (1.80–3.19)	<.0001	1.9 (1.71–2.12)	<.0001
201–349	1.2 (0.91–1.73)	0.15	1.19 (1.07–1.34)	0.001
>350	reference
Percent Undetectable
0–40%	reference
40–80%	0.68 (0.49–0.94)	0.02	0.76 (0.68–0.86)	<.0001
>80%	0.72 (0.51–1.00)	0.05	0.72 (0.64–0.8)	<.0001
Genotype
2 & 3 or unknown	reference
1 & 4	1.53 (1.18–1.99)	0.001	1.23 (1.12–1.36)	<.0001
Maximum BMI, > 30 kg/m2	0.84 (0.60–1.16)	0.28	0.85 (0.76–0.95)	0.005
Diabetes	1.24 (0.88–1.75)	0.20	1.15 (1.01–1.31)	0.04
Alcohol	1.04 (0.81–1.34)	0.75	1.15 (1.04–1.26)	0.004
Hypertension	1.07 (0.82–1.41)	0.61	1.09 (0.98–1.2)	0.096
Low-HDL	1.26 (0.97–1.64)	0.08	1.3 (1.2–1.44)	<.0001
Percent Statin (per 1%)	0.98 (0.97–0.99)	0.04	0.99(0.99–1.00)	0.43
Statin by 30% increment* (Point estimate)	0.68 (0.47–0.98)	-	0.95 (0.83–1.01)	-
Deaths stratified by statin (at time of death or last follow-up)
>30% statin use	33 (0.55)	<.0001	26 (0.4)	<.0001
≤30% statin use	974 (16.3)		812 (13.6)

^*The 30% point-estimate is a re-calculation of the 1% analysis to show a larger scale.