Fig. 2.

Schematic depiction of the contribution of astral and chromosome-associated microtubules to spindle formation. Only one centrosome of a spindle is shown for clarity. Astral microtubules (gray) mediate interactions with the cell cortex for spindle positioning (a) and cytokinesis (b); interact with kinetochores (c); with peripheral microtubules (d) and with microtubules from the opposite centrosome (e). Chromosome-associated microtubules (red) form dense arrays; molecular motors (orange) and microtubule-associated proteins (green) mediate the motion and bundling of these microtubules. Arrowheads depict microtubule plus-ends